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CLIC proteins are components or regulators of novel intracellular anion channels in mammalian cells, and previous studies have suggested that human nuclear membrane-associated CLIC1 and mouse inner mitochondrial membrane CLIC4 are involved in cell division and apoptosis. We have isolated Xenopus homologues of CLIC1 and CLIC4 and shown them to be well conserved during chordate evolution, but poorly conserved in invertebrates. Consistent with fundamental cellular roles, Xenopus CLIC genes are expressed at every stage of embryonic development. Expression is localised to mesodermal and ectodermal tissues, with particularly marked expression of xCLIC4 in the developing nervous system. This is the first description of non-mammalian CLIC expression, and use of Xenopus laevis as a model organism may provide insights into the role of CLIC-associated ion channels in animal development.
Ashley,
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2003, Pubmed
Ashley,
Challenging accepted ion channel biology: p64 and the CLIC family of putative intracellular anion channel proteins (Review).
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Pubmed
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Xenbase
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Pubmed
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Pubmed
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Pubmed
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2002,
Pubmed
Suginta,
Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms.
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Pubmed
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Pubmed
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Pubmed
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The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle.
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Pubmed
