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XB-ART-46881
Dev Biol. June 1, 2013; 378 (1): 1-12.

Different thresholds of Wnt-Frizzled 7 signaling coordinate proliferation, morphogenesis and fate of endoderm progenitor cells.



Abstract
Wnt signaling has multiple dynamic roles during development of the gastrointestinal and respiratory systems. Differential Wnt signaling is thought to be a critical step in Xenopus endoderm patterning such that during late gastrula and early somite stages of embryogenesis, Wnt activity must be suppressed in the anterior to allow the specification of foregut progenitors. However, the foregut endoderm also expresses the Wnt-receptor Frizzled 7 (Fzd7) as well as several Wnt ligands suggesting that the current model may be too simple. In this study, we show that Fzd7 is required to transduce a low level of Wnt signaling that is essential to maintain foregut progenitors. Foregut-specific Fzd7-depletion from the Xenopus foregut resulted in liver and pancreas agenesis. Fzd7-depleted embryos failed to maintain the foregut progenitor marker hhex and exhibited decreased proliferation; in addition the foregut cells were enlarged with a randomized orientation. We show that in the foregut Fzd7 signals via both the Wnt/β-catenin and Wnt/JNK pathways and that different thresholds of Wnt-Fzd7 activity coordinate progenitor cell fate, proliferation and morphogenesis.

PubMed ID: 23562607
Article link: Dev Biol.
Grant support: R01 DK070858 NIDDK NIH HHS , DK070858 NIDDK NIH HHS

Genes referenced: a2m casp3 cdc42 cdh1 cdh3 dkk1 fos fzd7 gsk3b hhex jun mapk8 nr1h5 pcyt1a pdx1 rac1 sfrp5 ventx1.2 ventx2.2 wnt11 wnt8a
Antibodies referenced:
Morpholinos referenced:
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