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XB-ART-4712
Dev Cell. September 1, 2003; 5 (3): 429-39.

Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate.



Abstract
The tail of the frog tadpole, comprising spinal cord, muscle, and notochord, regenerates following partial amputation. We show that, in Xenopus, this occurs throughout development, except for a "refractory period" between stages 45 and 47, when tails heal over without regeneration. Regeneration can be enabled during this refractory period by activation of either the BMP or Notch signaling pathways. Conversely, regeneration can be prevented during the later, regenerative, stages by inhibition of either pathway. BMP signaling will cause regeneration of all tissues, whereas Notch signaling activates regeneration of spinal cord and notochord, but not muscle. An activated form of Msx1 can promote regeneration in the same way as BMP signaling. Epistasis experiments suggest that BMP signaling is upstream of Notch signaling but exerts an independent effect on muscle regeneration. The results demonstrate that regenerative capability can be enabled by genetic modifications that reactivate specific components of the developmental program.

PubMed ID: 12967562
Article link: Dev Cell.

Genes referenced: bmpr1a dll1 hsp70 lfng msx1 msx2 myc nog notch1 t
Antibodies referenced: Lsamp Ab1
Article Images: [+] show captions

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