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Dev Cell September 1, 2003; 5 (3): 359-60.

Methylation gets SMRT. Functional insights into Rett syndrome.

Rett syndrome, a neurodevelopmental disorder, is caused by mutations in the methyl-CpG binding protein MeCP2. A recent report demonstrates that MeCP2 cooperates with the SMRT corepressor complex to inhibit expression of a hairy-related repressor during primary neurogenesis in Xenopus, and that this can be modulated by Notch signaling. Rett syndrome mutations that disrupt interaction with the SMRT corepressor complex also prevent regulation of MeCP2 by activated Notch."Well-timed silence hath more eloquence than speech."-Martin Farquhar Tupper (1810-1889)

PubMed ID: 12967552
Article link: Dev Cell

Species referenced: Xenopus
Genes referenced: dll1 hdac3 hes4 mecp2 ncor2 notch1 rbpj sin3a