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XB-ART-47219
Mol Cell Biol December 1, 1985; 5 (12): 3610-6.

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

Evan GI , Lewis GK , Ramsay G , Bishop JM .


Abstract
Six monoclonal antibodies have been isolated from mice immunized with synthetic peptide immunogens whose sequences are derived from that of the human c-myc gene product. Five of these antibodies precipitate p62c-myc from human cells, and three of these five also recognize the mouse c-myc gene product. None of the antibodies sees the chicken p110gag-myc protein. All six antibodies recognize immunoblotted p62c-myc. These reagents also provide the basis for an immunoblotting assay by which to quantitate p62c-myc in cells.

PubMed ID: 3915782
PMC ID: PMC369192
Article link: Mol Cell Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: myc

References [+] :
Alitalo, Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. 1983, Pubmed