XB-ART-47455
Prog Mol Biol Transl Sci
2013 Jan 01;116:387-407. doi: 10.1016/B978-0-12-394311-8.00017-0.
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Beta-catenin versus the other armadillo catenins: assessing our current view of canonical Wnt signaling.
Miller RK
,
Hong JY
,
Muñoz WA
,
McCrea PD
.
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The prevailing view of canonical Wnt signaling emphasizes the role of beta-catenin acting downstream of Wnt activation to regulate transcriptional activity. However, emerging evidence indicates that other armadillo catenins in vertebrates, such as members of the p120 subfamily, convey parallel signals to the nucleus downstream of canonical Wnt pathway activation. Their study is thus needed to appreciate the networked mechanisms of canonical Wnt pathway transduction, especially as they may assist in generating the diversity of Wnt effects observed in development and disease. In this chapter, we outline evidence of direct canonical Wnt effects on p120 subfamily members in vertebrates and speculate upon these catenins' roles in conjunction with or aside from beta-catenin.
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???displayArticle.grants??? [+]
1K01DK092320 NIDDK NIH HHS , GM052112 NIGMS NIH HHS , K01 DK092320 NIDDK NIH HHS , R01 GM052112 NIGMS NIH HHS , 1K01DK092320 NIDDK NIH HHS, K01 DK092320 NIDDK NIH HHS
Species referenced: Xenopus
Genes referenced: ctnnd1
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