Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
McCoy F
,
Darbandi R
,
Lee HC
,
Bharatham K
,
Moldoveanu T
,
Grace CR
,
Dodd K
,
Lin W
,
Chen SI
,
Tangallapally RP
,
Kurokawa M
,
Lee RE
,
Shelat AA
,
Chen T
,
Green DR
,
Harris RA
,
Lin SH
,
Fissore RA
,
Colbran RJ
,
Nutt LK
.
???displayArticle.abstract???
Active metabolism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caspase-2, but the link between metabolic activity and CaMKII is poorly understood. Here we identify coenzyme A (CoA) as the key metabolic signal that inhibits Xenopus laevis oocyte apoptosis by directly activating CaMKII. We found that CoA directly binds to the CaMKII regulatory domain in the absence of Ca(2+) to activate CaMKII in a calmodulin-dependent manner. Furthermore, we show that CoA inhibits apoptosis not only in X. laevis oocytes but also in Murine oocytes. These findings uncover a direct mechanism of CaMKII regulation by metabolism and further highlight the importance of metabolism in preserving oocyte viability.
Backs,
The gamma isoform of CaM kinase II controls mouse egg activation by regulating cell cycle resumption.
2010, Pubmed
Backs,
The gamma isoform of CaM kinase II controls mouse egg activation by regulating cell cycle resumption.
2010,
Pubmed
Berge,
Purification and characterization of long-chain acyl-CoA hydrolase from rat liver mitochondria.
1979,
Pubmed
Berge,
Dual localization of long-chain acyl-CoA hydrolase in rat liver: one in the microsomes and one in the mitochondrial matrix.
1979,
Pubmed
Bergeron,
Defects in regulation of apoptosis in caspase-2-deficient mice.
1998,
Pubmed
Bradshaw,
An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling.
2003,
Pubmed
Brickey,
Expression and characterization of the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II using the baculovirus expression system.
1990,
Pubmed
Chao,
Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.
2010,
Pubmed
Chao,
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.
2011,
Pubmed
Danial,
Cell death: critical control points.
2004,
Pubmed
DeBerardinis,
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.
2007,
Pubmed
Dworkin,
Metabolic regulation during early frog development: glycogenic flux in Xenopus oocytes, eggs, and embryos.
1989,
Pubmed
,
Xenbase
Erickson,
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation.
2008,
Pubmed
Evans,
Crk is required for apoptosis in Xenopus egg extracts.
1997,
Pubmed
,
Xenbase
Gosden,
Prospects for oocyte banking and in vitro maturation.
2005,
Pubmed
Hudmon,
Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II.
2002,
Pubmed
Jalan-Sakrikar,
Substrate-selective and calcium-independent activation of CaMKII by α-actinin.
2012,
Pubmed
Knudsen,
Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling.
1999,
Pubmed
Kuo,
Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia.
2005,
Pubmed
Kuttner,
A consensus-binding structure for adenine at the atomic level permits searching for the ligand site in a wide spectrum of adenine-containing complexes.
2003,
Pubmed
Kwiatkowski,
Autophosphorylation of the type II calmodulin-dependent protein kinase is essential for formation of a proteolytic fragment with catalytic activity. Implications for long-term synaptic potentiation.
1989,
Pubmed
Leonardi,
Coenzyme A: back in action.
2005,
Pubmed
Lobo,
Potential options for preservation of fertility in women.
2005,
Pubmed
McCoy,
Metabolic regulation of CaMKII protein and caspases in Xenopus laevis egg extracts.
2013,
Pubmed
,
Xenbase
Nutt,
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.
2005,
Pubmed
,
Xenbase
Nutt,
Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2.
2009,
Pubmed
,
Xenbase
Nutt,
The Xenopus oocyte: a model for studying the metabolic regulation of cancer cell death.
2012,
Pubmed
,
Xenbase
Perez,
Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction.
1997,
Pubmed
Reitzer,
Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.
1979,
Pubmed
Rellos,
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
2010,
Pubmed
Rich,
Proteolytic activation of calcium/calmodulin-dependent protein kinase II: Putative function in synaptic plasticity.
1990,
Pubmed
Robishaw,
Coenzyme A metabolism.
1985,
Pubmed
Shifman,
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums.
2006,
Pubmed
Smith,
Functional determinants in the autoinhibitory domain of calcium/calmodulin-dependent protein kinase II. Role of His282 and multiple basic residues.
1992,
Pubmed
Smythe,
Systems for the study of nuclear assembly, DNA replication, and nuclear breakdown in Xenopus laevis egg extracts.
1991,
Pubmed
,
Xenbase
WARBURG,
On the origin of cancer cells.
1956,
Pubmed
Wellen,
ATP-citrate lyase links cellular metabolism to histone acetylation.
2009,
Pubmed
Yang,
Structural examination of autoregulation of multifunctional calcium/calmodulin-dependent protein kinase II.
1999,
Pubmed
Zhang,
Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.
2007,
Pubmed
