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Trends Neurosci September 1, 2003; 26 (9): 453-5.

Dishevelled: linking convergent extension with neural tube closure.

Copp AJ , Greene ND , Murdoch JN .

Neural tube closure fails in both mouse and Xenopus when dishevelled and other components of the planar-cell-polarity pathway are misregulated. The underlying defect involves a failure of convergent extension in the midline of the early neural plate. Although bilateral neural folds form, they are abnormally far apart and cannot achieve the apposition necessary for neural tube closure.

PubMed ID: 12948650
Article link: Trends Neurosci

Genes referenced: dvl2

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