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XB-ART-47805
Genesis February 1, 2014; 52 (2): 120-6.

Protocadherin PAPC is expressed in the CNC and can compensate for the loss of PCNS.

Schneider M , Huang C , Becker SF , Gradl D , Wedlich D .


Abstract
Protocadherins represent the biggest subgroup within the cadherin superfamily of transmembrane glycoproteins. In contrast to classical type I cadherins, protocadherins in general exhibit only moderate adhesive activity. During embryogenesis, they are involved in cell signaling and regulate diverse morphogenetic processes, including morphogenetic movements during gastrulation and neural crest migration. The two protocadherins paraxial protocadherin (PAPC) and axial protocadherin (AXPC) are indispensable for proper gastrulation movements in Xenopus and zebrafish. The closest relative PCNS instead, is required for neural crest and somite formation. Here, we show that cranial neural crest (CNC) cells in addition to PCNS express PAPC, but not AXPC. Overexpression of PAPC resulted in comparable migration defects as knockdown of PCNS. Moreover, reconstitution experiments revealed that PAPC is able to replace PCNS in CNC cells, indicating that both protocadherins can regulate CNC migration.

PubMed ID: 24339193
Article link: Genesis


Species referenced: Xenopus
Genes referenced: odc1 pcdh1 pcdh8 pcdh8.2 pcdh8l snai1 snai2 twist1
Morpholinos: pcdh8.2 MO1 pcdh8.2 MO2 pcdh8l MO1


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