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Development. October 1, 2013; 140 (20): 4177-81.

Coco regulates dorsoventral specification of germ layers via inhibition of TGFβ signalling.

Bates TJ , Vonica A , Heasman J , Brivanlou AH , Bell E .

One of the earliest steps in embryonic development is the specification of the germ layers, the subdivision of the blastula embryo into endoderm, mesoderm and ectoderm. Maternally expressed members of the Transforming Growth Factor β (TGFβ) family influence all three germ layers; the ligands are required to induce endoderm and mesoderm, whereas inhibitors are required for formation of the ectoderm. Here, we demonstrate a vital role for maternal Coco, a secreted antagonist of TGFβ signalling, in this process. We show that Coco is required to prevent Activin and Nodal signals in the dorsal marginal side of the embryo from invading the prospective ectoderm, thereby restricting endoderm- and mesoderm-inducing signals to the vegetal and marginal zones of the pre-gastrula Xenopus laevis embryo.

PubMed ID: 24026124
PMC ID: PMC3787757
Article link: Development.
Grant support: G120/782 Medical Research Council , R01 GM084951 Medical Research Council , R03 HD057334-01A2 NICHD NIH HHS , R03 HD057334 NICHD NIH HHS , G120/782 Medical Research Council , R01 GM084951 Medical Research Council , R03 HD057334-01A2 NICHD NIH HHS , R01 GM084951 NIGMS NIH HHS

Genes referenced: chrd.1 dand5 gal.2 gsc hoxb9 inhbb myod1 nodal nodal5 nodal5.2 nodal6 smad2 sox17b.1 t hoxc9-like

Antibodies referenced: Dand5 Ab1 Smad2 Ab5
Morpholinos referenced: dand5 MO1 inhbb MO6 nodal5.2 MO1 nodal6 MO1

Agius, 2000, Pubmed, Xenbase[+]

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