Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-47908
Development October 1, 2013; 140 (20): 4177-81.

Coco regulates dorsoventral specification of germ layers via inhibition of TGFβ signalling.

Bates TJ , Vonica A , Heasman J , Brivanlou AH , Bell E .


Abstract
One of the earliest steps in embryonic development is the specification of the germ layers, the subdivision of the blastula embryo into endoderm, mesoderm and ectoderm. Maternally expressed members of the Transforming Growth Factor β (TGFβ) family influence all three germ layers; the ligands are required to induce endoderm and mesoderm, whereas inhibitors are required for formation of the ectoderm. Here, we demonstrate a vital role for maternal Coco, a secreted antagonist of TGFβ signalling, in this process. We show that Coco is required to prevent Activin and Nodal signals in the dorsal marginal side of the embryo from invading the prospective ectoderm, thereby restricting endoderm- and mesoderm-inducing signals to the vegetal and marginal zones of the pre-gastrula Xenopus laevis embryo.

PubMed ID: 24026124
PMC ID: PMC3787757
Article link: Development
Grant support: [+]
Genes referenced: chrd.1 dand5 gal.2 gsc hoxb9 hoxc9-like inhbb myod1 nodal nodal1 nodal5 nodal5.2 nodal6 smad2 sox17b.1 tbxt
Antibodies: Dand5 Ab1 Smad2 Ab5
Morpholinos: dand5 MO1 inhbb MO6 nodal5.2 MO1 nodal6 MO1


Article Images: [+] show captions
References:
Agius, 2000, Pubmed, Xenbase [+]


Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.12.0


Major funding for Xenbase is provided by grant P41 HD064556