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Curr Biol August 5, 2013; 23 (15): R652-4.

Development: scaling to size by protease inhibition.

The dorsal half of bisected Xenopus laevis embryos can regenerate a well-proportioned organism on a smaller scale. A new study indicates that the removal of ventral tissue generates a steeper Chordin gradient by reducing Sizzled, a secreted inhibitor of Tolloid chordinases.

PubMed ID: 23928082
Article link: Curr Biol
Grant support: [+]
Genes referenced: bmp1 chrd.1 frzb2 szl
Morpholinos: chrd MO1 chrd MO2 szl MO1

Article Images: [+] show captions
References :
Inomata, Scaling of dorsal-ventral patterning by embryo size-dependent degradation of Spemann's organizer signals. 2013, Pubmed, Xenbase

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