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Curr Biol August 5, 2013; 23 (15): R652-4.

Development: scaling to size by protease inhibition.

The dorsal half of bisected Xenopus laevis embryos can regenerate a well-proportioned organism on a smaller scale. A new study indicates that the removal of ventral tissue generates a steeper Chordin gradient by reducing Sizzled, a secreted inhibitor of Tolloid chordinases.

PubMed ID: 23928082
Article link: Curr Biol
Grant support: Howard Hughes Medical Institute

Genes referenced: bmp1 chrd.1 frzb2 szl

Morpholinos referenced: chrd MO1 chrd MO2 szl MO1

External Resources:
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Inomata, 2013, Pubmed, Xenbase

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