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XB-ART-48041
PLoS One January 1, 2013; 8 (7): e69372.

sox4 and sox11 function during Xenopus laevis eye development.

Cizelsky W , Hempel A , Metzig M , Tao S , Hollemann T , Kühl M , Kühl SJ .


Abstract
SoxC genes are involved in many developmental processes such as cardiac, lymphoid, and bone development. The SoxC gene family is represented by Sox4, Sox11, and Sox12. Loss of either Sox4 or Sox11 function is lethal during mouse embryogenesis. Here, we demonstrate that sox4 and sox11 are strongly expressed in the developing eye, heart as well as brain in Xenopus laevis. Morpholino oligonucleotide mediated knock-down approaches in anterior neural tissue revealed that interference with either Sox4 or Sox11 function affects eye development. A detailed analysis demonstrated strong effects on eye size and retinal lamination. Neural induction was unaffected upon Sox4 or Sox11 MO injection and early eye field differentiation and cell proliferation were only mildly affected. Depletion of both genes, however, led independently to a significant increase in cell apoptosis in the eye. In summary, Sox4 and Sox11 are required for Xenopus visual system development.

PubMed ID: 23874955
PMC ID: PMC3715537
Article link: PLoS One

Genes referenced: arr3 cry1 egr2 emx1 emx1l en2 foxe3 neurod1 otx2 pax6 pou4f1 prox1 rax rho six3 sox11 sox12 sox13 sox3 sox4 tp53 vsx1
Morpholinos: sox11 MO1 sox4 MO1 tp53 MO1


Article Images: [+] show captions
References:
Bergsland, 2006, Pubmed [+]


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