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Development June 1, 2013; 140 (11): 2247-51.

The neural crest.

The neural crest (NC) is a highly migratory multipotent cell population that forms at the interface between the neuroepithelium and the prospective epidermis of a developing embryo. Following extensive migration throughout the embryo, NC cells eventually settle to differentiate into multiple cell types, ranging from neurons and glial cells of the peripheral nervous system to pigment cells, fibroblasts to smooth muscle cells, and odontoblasts to adipocytes. NC cells migrate in large numbers and their migration is regulated by multiple mechanisms, including chemotaxis, contact-inhibition of locomotion and cell sorting. Here, we provide an overview of NC formation, differentiation and migration, highlighting the molecular mechanisms governing NC migration.

PubMed ID: 23674598
Article link: Development
Grant support: Biotechnology and Biological Sciences Research CouncilMedical Research CouncilWellcome Trust , MR/J000655/1 Medical Research Council , MRC_MR/J000655/1 Medical Research Council

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