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XB-ART-48207
Biochem Biophys Res Commun 2013 Feb 15;4313:388-92. doi: 10.1016/j.bbrc.2013.01.042.
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Reconstitution of functionally efficient SecA-dependent protein-conducting channels: transformation of low-affinity SecA-liposome channels to high-affinity SecA-SecYEG-SecDF·YajC channels.

Hsieh YH , Zhang H , Wang H , Yang H , Jiang C , Sui SF , Tai PC .


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Previous work showed that SecA alone can promote protein translocation and ion-channel activity in liposomes, and that SecYEG increases efficiency as well as signal peptide specificity. We now report that SecDF·YajC further increases translocation and ion-channel activity. These activities of reconstituted SecA-SecYEG-SecDF·YajC-liposome are almost the same as those of native membranes, indicating the transformation of reconstituted functional high-affinity protein-conducting channels from the low-affinity SecA-channels.

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