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XB-ART-48214
Cell Mol Life Sci September 1, 2013; 70 (18): 3289-302.

Transcriptional regulation and nuclear reprogramming: roles of nuclear actin and actin-binding proteins.



Abstract
Proper regulation of transcription is essential for cells to acquire and maintain cell identity. Transcriptional activation plays a central role in gene regulation and can be modulated by introducing transcriptional activators such as transcription factors. Activators act on their specific target genes to induce transcription. Reprogramming experiments have revealed that as cells become differentiated, some genes are highly silenced and even introduction of activators that target these silenced genes does not induce transcription. This can be explained by chromatin-based repression that restricts access of transcriptional activators to silenced genes. Transcriptional activation from these genes can be accomplished by opening chromatin, in addition to providing activators. Once a de novo transcription network is established, cells are differentiated or reprogrammed to a new cell type. Emerging evidence suggests that actin in the nucleus (nuclear actin) and nuclear actin-binding proteins are implicated in these transcriptional regulatory processes. This review summarizes roles of nuclear actin and actin-binding proteins in transcriptional regulation. We also discuss possible functions of nuclear actin during reprogramming in the context of transcription and chromatin remodeling.

PubMed ID: 23275942
PMC ID: PMC3753470
Article link: Cell Mol Life Sci
Grant support: [+]
Genes referenced: actl6a aicda banf1 coro1c hnrnpc nono pknox1 pou5f3.1 rab40b sfpq srf tirap was wasl xpo6


Article Images: [+] show captions
References:
Ambrosino, 2010, Pubmed [+]


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