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XB-ART-48477
Dev Dyn. September 23, 2017;

Fgfr signaling is required as the early eye field forms to promote later patterning and morphogenesis of the eye.



Abstract
Background: A major step in eye morphogenesis is the transition from optic vesicle to optic cup, which occurs as a ventral groove forms along the base of the optic vesicle. A ventral gap in the eye, or coloboma, results when this groove fails to close. Extrinsic signals, such as fibroblast growth factors (Fgfs), play a critical role in the development and morphogenesis of the vertebrate eye. Whether these extrinsic signals are required throughout eye development, or within a defined critical period remains an unanswered question. Results: Here we show that an early Fgf signal, required as the eye field is first emerging, drives eye morphogenesis. In addition to triggering coloboma, inhibition of this early Fgf signal results in defects in dorsal-ventral patterning of the neural retina, particularly in the nasal retina, and development of the periocular mesenchyme (POM). These processes are unaffected by inhibition of Fgfr signaling at later time points. Conclusions: We propose that Fgfs act within an early critical period as the eye field forms to promote development of the neural retina and POM, which subsequently drive eye morphogenesis. Developmental Dynamics, 2014. © 2014 Wiley Periodicals, Inc.

PubMed ID: 24478172
Article link: Dev Dyn.

Genes referenced: aldh1a3 bmp4 calb1 fgfr2 foxc1 gnl3 isl1 rho tbx3 vax2



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