XB-ART-4850Dev Cell. April 1, 2017; 5 (2): 187-8.
The quest for the holy "G" of chromosomal passengers.
Twelve years after reporting a novel chromosomal passenger protein, Mollinari et al. in this issue of Developmental Cell finally report its molecular identification, and the results are stunning. TD-60 is a member of the RCC1 family of guanine nucleotide exchange factors implicating small GTPases in chromosome congression and cytokinesis.
PubMed ID: 12919667
Article link: Dev Cell.
Genes referenced: aurka aurkb incenp kpna1 kpnb1 rac1 ran rcc1 tbx2 tpx2
Mollinari, 2003, Pubmed