XB-ART-48735Semin Immunopathol. March 1, 2014; 36 (2): 211-26.
JAM-related proteins in mucosal homeostasis and inflammation.
Mucosal surfaces are lined by epithelial cells that form a physical barrier protecting the body against external noxious substances and pathogens. At a molecular level, the mucosal barrier is regulated by tight junctions (TJs) that seal the paracellular space between adjacent epithelial cells. Transmembrane proteins within TJs include junctional adhesion molecules (JAMs) that belong to the cortical thymocyte marker for Xenopus family of proteins. JAM family encompasses three classical members (JAM-A, JAM-B, and JAM-C) and related molecules including JAM4, JAM-like protein, Coxsackie and adenovirus receptor (CAR), CAR-like membrane protein and endothelial cell-selective adhesion molecule. JAMs have multiple functions that include regulation of endothelial and epithelial paracellular permeability, leukocyte recruitment during inflammation, angiogenesis, cell migration, and proliferation. In this review, we summarize the current knowledge regarding the roles of the JAM family members in the regulation of mucosal homeostasis and leukocyte trafficking with a particular emphasis on barrier function and its perturbation during pathological inflammation.
PubMed ID: 24667924
PMC ID: PMC4084508
Article link: Semin Immunopathol.
Grant support: DK055679 NIDDK NIH HHS , DK059888 NIDDK NIH HHS , DK061379 NIDDK NIH HHS , DK064399 NIDDK NIH HHS , DK072564 NIDDK NIH HHS , DK072564 NIDDK NIH HHS , R01 DK079392 NIDDK NIH HHS , R29 DK055679 NIDDK NIH HHS , DK079392 NIDDK NIH HHS , DK061379 NIDDK NIH HHS , R01 DK072564 NIDDK NIH HHS , R24 DK064399 NIDDK NIH HHS , DK055679 NIDDK NIH HHS , R01 DK055679 NIDDK NIH HHS , R01 DK061379 NIDDK NIH HHS , DK059888 NIDDK NIH HHS , DK064399 NIDDK NIH HHS , R01 DK059888 NIDDK NIH HHS
Genes referenced: f11r igsf5