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XB-ART-48899
Development May 1, 2014; 141 (10): 2064-74.

The Wnt/JNK signaling target gene alcam is required for embryonic kidney development.

Cizelsky W , Tata A , Kühl M , Kühl SJ .


Abstract
Proper development of nephrons is essential for kidney function. β-Catenin-independent Wnt signaling through Fzd8, Inversin, Daam1, RhoA and Myosin is required for nephric tubule morphogenesis. Here, we provide a novel mechanism through which non-canonical Wnt signaling contributes to tubular development. Using Xenopus laevis as a model system, we found that the cell-adhesion molecule Alcam is required for proper nephrogenesis and functions downstream of Fzd3 during embryonic kidney development. We found alcam expression to be independent of Fzd8 or Inversin, but to be transcriptionally regulated by the β-Catenin-independent Wnt/JNK pathway involving ATF2 and Pax2 in a direct manner. These novel findings indicate that several branches of Wnt signaling are independently required for proximal tubule development. Moreover, our data indicate that regulation of morphogenesis by non-canonical Wnt ligands also involves direct transcriptional responses in addition to the effects on a post-translational level.

PubMed ID: 24764076
Article link: Development


Species referenced: Xenopus laevis
Genes referenced: alcam atf2 clcnkb ctnnb1 daam1 foxc1 foxc2 fxyd2 fzd3 fzd8 invs lhx1 mapk8 myod1 pax2 rhoa slc12a1 slc26a11 slc5a1.1 slc5a1.2 slc7a8 tbx2 thibz wnt4


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