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XB-ART-48960
Dokl Biol Sci 2014 Mar 01;4551:136-8. doi: 10.1134/S0012496614020185.
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Thyroid hormones in the skeletogenesis and accessory sources of endogenous hormones in Xenopus laevis (Amphibia; Anura) ontogeny: Experimental evidence.

Smirnov SV , Vassilieva AB .


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Skeletal development was studied in normal and goitrogen-treated Xenopus laevis tadpoles reared under thyroid hormone (TH) deficiency. Early stages of skeletal development proceed similarly in both groups. Later stages are retarded or completely arrested in goitrogen-treated tadpoles. After goitrogen-treated tadpoles were transferred into pure water or into a medium containing both goitrogen and exogenous TH, tadpoles resumed development. Consequently, late stages of skeletogenesis are TH-dependent and TH-induced. Athyroid X. laevis "giant tadpoles" described in literature differ from goitrogen-arrested tadpoles in that they have features which require TH to appear. The appearance of TH-depended features in giant tadpoles indicates the occurrence of the additional sources of TH other than thyroid gland.

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Species referenced: Xenopus laevis

References [+] :
Brown, Thyroid hormone controls multiple independent programs required for limb development in Xenopus laevis metamorphosis. 2005, Pubmed, Xenbase