XB-ART-48976Cell October 2, 1998; 95 (1): 67-80.
Specification of motor neuron identity by the MNR2 homeodomain protein.
Sonic hedgehog signaling controls the differentiation of motor neurons in the ventral neural tube, but the intervening steps are poorly understood. A differential screen of a cDNA library derived from a single Shh-induced motor neuron has identified a novel homeobox gene, MNR2, expressed by motor neuron progenitors and transiently by postmitotic motor neurons. The ectopic expression of MNR2 in neural cells initiates a program of somatic motor neuron differentiation characterized by the expression of homeodomain proteins, by neurotransmitter phenotype, and by axonal trajectory. Our results suggest that the Shh-mediated induction of a single transcription factor, MNR2, is sufficient to direct somatic motor neuron differentiation.
PubMed ID: 9778248
Article link: Cell
Species referenced: Xenopus laevis
Genes referenced: mnx1 shh
Antibodies: Mnx1 Ab1