Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Dev Neurosci
2014 Jan 01;366:443-53. doi: 10.1159/000364858.
Show Gene links
Show Anatomy links
G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate.
Fincher J
,
Whiteneck C
,
Birgbauer E
.
???displayArticle.abstract???
In the development of the nervous system, one of the critical aspects is the proper navigation of axons to their targets, i.e. the problem of axonal guidance. We used the chick visual system as a model to investigate the role of the lysophospholipids lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) as potential axon guidance cues. We showed that both LPA and S1P cause a specific, dose-dependent growth cone collapse of retinal neurons in vitro in the chick model system, with slight differences compared to the mouse but very similar to observations in Xenopus. Because LPA and S1P receptors are G-protein-coupled receptors, we analyzed the intracellular signaling pathways using pharmacological inhibitors in chick retinal neurons. Blocking rho kinase (ROCK) prevented growth cone collapse by LPA and S1P, while blocking PLC or chelating calcium had no effect on growth cone collapse. Inhibition of Gi/o with pertussis toxin resulted in a partial reduction of growth cone collapse, both with LPA and with S1P. Inhibition of p38 blocked growth cone collapse mediated by LPA but not S1P. Thus, in addition to the involvement of the G12/13-ROCK pathway, LPA- and S1P-induced collapse of chick retinal growth cones has a partial requirement for Gi/o.
Anliker,
Lysophospholipid G protein-coupled receptors.
2004, Pubmed
Anliker,
Lysophospholipid G protein-coupled receptors.
2004,
Pubmed
Bagri,
Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.
2002,
Pubmed
Bates,
Heterotrimeric G protein activation rapidly inhibits outgrowth of optic axons from adult and embryonic mouse, and goldfish retinal explants.
1996,
Pubmed
Behar,
Semaphorin III is needed for normal patterning and growth of nerves, bones and heart.
1996,
Pubmed
Birgbauer,
New developments in the biological functions of lysophospholipids.
2006,
Pubmed
Birgbauer,
Lysophospholipid receptors LPA1-3 are not required for the inhibitory effects of LPA on mouse retinal growth cones.
2010,
Pubmed
Bito,
A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons.
2000,
Pubmed
Brennan,
Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish.
1997,
Pubmed
Campbell,
Semaphorin 3A elicits stage-dependent collapse, turning, and branching in Xenopus retinal growth cones.
2001,
Pubmed
,
Xenbase
Campbell,
Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation.
2001,
Pubmed
,
Xenbase
Campbell,
Apoptotic pathway and MAPKs differentially regulate chemotropic responses of retinal growth cones.
2003,
Pubmed
,
Xenbase
Chalasani,
A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding.
2003,
Pubmed
Chun,
International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature.
2010,
Pubmed
Chun,
International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature.
2002,
Pubmed
Clark,
Neuronal platelet-activating factor receptor signal transduction involves a pertussis toxin-sensitive G-protein.
2000,
Pubmed
Davenport,
Cellular localization of ephrin-A2, ephrin-A5, and other functional guidance cues underlies retinotopic development across species.
1998,
Pubmed
Deiner,
Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia.
1997,
Pubmed
Deiner,
Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice.
1999,
Pubmed
Drescher,
In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases.
1995,
Pubmed
Erskine,
The retinal ganglion cell axon's journey: insights into molecular mechanisms of axon guidance.
2007,
Pubmed
Erskine,
Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits.
2000,
Pubmed
Etienne-Manneville,
Rho GTPases in cell biology.
2002,
Pubmed
Fan,
Localized collapsing cues can steer growth cones without inducing their full collapse.
1995,
Pubmed
Feldheim,
Visual map development: bidirectional signaling, bifunctional guidance molecules, and competition.
2010,
Pubmed
Feldheim,
Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping.
2000,
Pubmed
Frisén,
Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system.
1998,
Pubmed
Goshima,
A novel action of collapsin: collapsin-1 increases antero- and retrograde axoplasmic transport independently of growth cone collapse.
1997,
Pubmed
Höpker,
Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1.
1999,
Pubmed
,
Xenbase
Jalink,
Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action.
1993,
Pubmed
Jalink,
Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.
1994,
Pubmed
Jin,
Rac1 mediates collapsin-1-induced growth cone collapse.
1997,
Pubmed
Kaslow,
Pertussis toxin and target eukaryotic cells: binding, entry, and activation.
1992,
Pubmed
Katada,
Slow interaction of islet-activating protein with pancreatic islets during primary culture to cause reversal of alpha-adrenergic inhibition of insulin secretion.
1980,
Pubmed
Katada,
Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.
1982,
Pubmed
Kozma,
Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid.
1997,
Pubmed
Kuhn,
Myelin and collapsin-1 induce motor neuron growth cone collapse through different pathways: inhibition of collapse by opposing mutants of rac1.
1999,
Pubmed
Luo,
Rho GTPases in neuronal morphogenesis.
2000,
Pubmed
Luo,
Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones.
1993,
Pubmed
MacLennan,
Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth.
2000,
Pubmed
Meima,
Lerk2 (ephrin-B1) is a collapsing factor for a subset of cortical growth cones and acts by a mechanism different from AL-1 (ephrin-A5).
1997,
Pubmed
Meima,
AL-1-induced growth cone collapse of rat cortical neurons is correlated with REK7 expression and rearrangement of the actin cytoskeleton.
1997,
Pubmed
Ming,
cAMP-dependent growth cone guidance by netrin-1.
1997,
Pubmed
,
Xenbase
Murakami,
Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.
2008,
Pubmed
Nakayama,
Role of cdk5 and tau phosphorylation in heterotrimeric G protein-mediated retinal growth cone collapse.
1999,
Pubmed
Niclou,
Slit2 is a repellent for retinal ganglion cell axons.
2000,
Pubmed
Ohuchi,
Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development.
2007,
Pubmed
Ohuchi,
Autotaxin controls caudal diencephalon-mesencephalon development in the chick.
2010,
Pubmed
Oster,
Invariant Sema5A inhibition serves an ensheathing function during optic nerve development.
2003,
Pubmed
Oster,
Ganglion cell axon pathfinding in the retina and optic nerve.
2004,
Pubmed
Pasternack,
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.
2008,
Pubmed
Pfeiffenberger,
Ephrin-As and patterned retinal activity act together in the development of topographic maps in the primary visual system.
2006,
Pubmed
Plump,
Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system.
2002,
Pubmed
Postma,
Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.
1996,
Pubmed
Raper,
The enrichment of a neuronal growth cone collapsing activity from embryonic chick brain.
1990,
Pubmed
Ridley,
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.
1992,
Pubmed
Ringstedt,
Slit inhibition of retinal axon growth and its role in retinal axon pathfinding and innervation patterns in the diencephalon.
2000,
Pubmed
Saito,
Effects of lysophosphatidic acid on primary cultured chick neurons.
1997,
Pubmed
Sato,
Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells.
1997,
Pubmed
Sato,
Unmasking of LPA1 receptor-mediated migration response to lysophosphatidic acid by interleukin-1β-induced attenuation of Rho signaling pathways in rat astrocytes.
2011,
Pubmed
Song,
Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.
1998,
Pubmed
,
Xenbase
Strochlic,
A role for S1P signalling in axon guidance in the Xenopus visual system.
2008,
Pubmed
,
Xenbase
Tabata,
The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.
2007,
Pubmed
Taniguchi,
Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection.
1997,
Pubmed
Tigyi,
Lysophosphatidic acid-induced neurite retraction in PC12 cells: control by phosphoinositide-Ca2+ signaling and Rho.
1996,
Pubmed
Tigyi,
Lysophosphatidic acid-induced neurite retraction in PC12 cells: neurite-protective effects of cyclic AMP signaling.
1996,
Pubmed
Twery,
SDF1-induced antagonism of axonal repulsion requires multiple G-protein coupled signaling components that work in parallel.
2011,
Pubmed
Ulupinar,
Role of semaphorin III in the developing rodent trigeminal system.
1999,
Pubmed
Van Leeuwen,
Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.
2003,
Pubmed
Wahl,
Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase.
2000,
Pubmed
Yanagida,
LPA4/p2y9/GPR23 mediates rho-dependent morphological changes in a rat neuronal cell line.
2007,
Pubmed
Yanagida,
Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6.
2009,
Pubmed
Zhang,
Rho-dependent contractile responses in the neuronal growth cone are independent of classical peripheral retrograde actin flow.
2003,
Pubmed
de Curtis,
Functions of Rac GTPases during neuronal development.
2008,
Pubmed
,
Xenbase
