Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-49481
Dev Biol January 15, 2015; 397 (2): 282-92.

Evolutionarily conserved role for SoxC genes in neural crest specification and neuronal differentiation.

Uy BR , Simoes-Costa M , Koo DE , Sauka-Spengler T , Bronner ME .


Abstract
Members of the Sox family of transcription factors play a variety of critical developmental roles in both vertebrates and invertebrates. Whereas SoxBs and SoxEs are involved in neural and neural crest development, respectively, far less is known about members of the SoxC subfamily. To address this from an evolutionary perspective, we compare expression and function of SoxC genes in neural crest cells and their derivatives in lamprey (Petromyzon marinus), a basal vertebrate, to frog (Xenopus laevis). Analysis of transcript distribution reveals conservation of lamprey and X. laevis SoxC expression in premigratory neural crest, branchial arches, and cranial ganglia. Moreover, morpholino-mediated loss-of-function of selected SoxC family members demonstrates essential roles in aspects of neural crest development in both organisms. The results suggest important and conserved functions of SoxC genes during vertebrate evolution and a particularly critical, previously unrecognized role in early neural crest specification.

PubMed ID: 25286121
PMC ID: PMC4545591
Article link: Dev Biol
Grant support: [+]
Genes referenced: foxd3 neurog2 sox10 sox11 sox12 sox13 sox4 twist1
Morpholinos: sox11 MO2 sox12 MO1 sox4 MO2


Article Images: [+] show captions
References:
Bell, 2000, Pubmed [+]


Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.11.2


Major funding for Xenbase is provided by grant P41 HD064556