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Pflugers Arch
2015 May 01;4675:945-58. doi: 10.1007/s00424-014-1634-8.
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Properties, regulation, pharmacology, and functions of the K₂p channel, TRESK.
Enyedi P
,
Czirják G
.
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TWIK-related spinal cord K(+) channel (TRESK) is the gene product of KCNK18, the last discovered leak potassium K2P channel gene. Under resting conditions, TRESK is constitutively phosphorylated at two regulatory regions. Protein kinase A (PKA) and microtubule affinity-regulating (MARK) kinases can be applied in experiments to phosphorylate these sites of TRESK expressed in Xenopus oocytes, respectively. Upon generation of a calcium signal, TRESK is dephosphorylated and thereby activated by calcineurin. In this process, the binding of calcineurin to the channel by non-catalytic interacting sites is essential. The phosphorylation/dephosphorylation regulatory process is modified by 14-3-3 proteins. Human, but not murine TRESK is also activated by protein kinase C. TRESK is expressed most abundantly in sensory neurons of the dorsal root ganglia (DRG) and trigeminal ganglia, and the channel modifies certain forms of nociceptive afferentation. In a large pedigree, a dominant negative mutant TRESK allele was found to co-segregate perfectly with migraine phenotype. While this genetic defect may be responsible only for a very small fraction of migraine cases, specific TRESK activation is expected to exert beneficial effect in common forms of the disease.
Albin,
Psychophysical evaluation of a sanshool derivative (alkylamide) and the elucidation of mechanisms subserving tingle.
2010, Pubmed
Albin,
Psychophysical evaluation of a sanshool derivative (alkylamide) and the elucidation of mechanisms subserving tingle.
2010,
Pubmed
Andres-Enguix,
Functional analysis of missense variants in the TRESK (KCNK18) K channel.
2012,
Pubmed
Anttila,
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
2013,
Pubmed
Bautista,
Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels.
2008,
Pubmed
Bobak,
Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels.
2011,
Pubmed
Braun,
TRESK background K(+) channel is inhibited by PAR-1/MARK microtubule affinity-regulating kinases in Xenopus oocytes.
2011,
Pubmed
,
Xenbase
Brohawn,
Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel.
2012,
Pubmed
Bruner,
Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel.
2014,
Pubmed
Cadaveira-Mosquera,
Expression of K2P channels in sensory and motor neurons of the autonomic nervous system.
2012,
Pubmed
Chae,
Discrete change in volatile anesthetic sensitivity in mice with inactivated tandem pore potassium ion channel TRESK.
2010,
Pubmed
Cooper,
Characterization and function of TWIK-related acid sensing K+ channels in a rat nociceptive cell.
2004,
Pubmed
Czirják,
TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways.
2010,
Pubmed
,
Xenbase
Czirják,
Zinc and mercuric ions distinguish TRESK from the other two-pore-domain K+ channels.
2006,
Pubmed
,
Xenbase
Czirják,
Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK.
2006,
Pubmed
,
Xenbase
Czirják,
The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel.
2014,
Pubmed
Czirják,
The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin.
2004,
Pubmed
,
Xenbase
Czirják,
Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation.
2008,
Pubmed
,
Xenbase
Dobler,
TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones.
2007,
Pubmed
,
Xenbase
Enyedi,
Tubulin binds to the cytoplasmic loop of TRESK background K⁺ channel in vitro.
2014,
Pubmed
Gohlke,
SuperPain--a resource on pain-relieving compounds targeting ion channels.
2014,
Pubmed
Guo,
Nonmigraine-associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons.
2014,
Pubmed
,
Xenbase
Guo,
Over-expression of TRESK K(+) channels reduces the excitability of trigeminal ganglion nociceptors.
2014,
Pubmed
Han,
TRESK channel as a potential target to treat T-cell mediated immune dysfunction.
2009,
Pubmed
Kang,
Lamotrigine inhibits TRESK regulated by G-protein coupled receptor agonists.
2008,
Pubmed
Kang,
TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons.
2006,
Pubmed
Kang,
Functional expression of TRESK-2, a new member of the tandem-pore K+ channel family.
2004,
Pubmed
Keshavaprasad,
Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK.
2005,
Pubmed
Kim,
Identification of blocker binding site in mouse TRESK by molecular modeling and mutational studies.
2013,
Pubmed
Koo,
Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons.
2007,
Pubmed
Lafrenière,
A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.
2010,
Pubmed
Lennertz,
Physiological basis of tingling paresthesia evoked by hydroxy-alpha-sanshool.
2010,
Pubmed
Liu,
Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics.
2004,
Pubmed
,
Xenbase
Liu,
Two independent calcineurin-binding regions in the N-terminal domain of murine NF-ATx1 recruit calcineurin to murine NF-ATx1.
1999,
Pubmed
Liu,
Functional analysis of a migraine-associated TRESK K+ channel mutation.
2013,
Pubmed
,
Xenbase
Maher,
Analysis of 3 common polymorphisms in the KCNK18 gene in an Australian Migraine case-control cohort.
2013,
Pubmed
Manteniotis,
Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in Trigeminal ganglia.
2013,
Pubmed
Marsh,
Leak K⁺ channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviour.
2012,
Pubmed
Matenia,
The tau of MARK: a polarized view of the cytoskeleton.
2009,
Pubmed
Medhurst,
Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery.
2001,
Pubmed
Menozzi-Smarrito,
Synthesis and evaluation of new alkylamides derived from alpha-hydroxysanshool, the pungent molecule in szechuan pepper.
2009,
Pubmed
Miller,
Crystal structure of the human two-pore domain potassium channel K2P1.
2012,
Pubmed
Nyholt,
A high-density association screen of 155 ion transport genes for involvement with common migraine.
2008,
Pubmed
Patel,
Inhalational anesthetics activate two-pore-domain background K+ channels.
1999,
Pubmed
Pollema-Mays,
Expression of background potassium channels in rat DRG is cell-specific and down-regulated in a neuropathic pain model.
2013,
Pubmed
Pottosin,
TRESK-like potassium channels in leukemic T cells.
2008,
Pubmed
Rahm,
Functional characterization of zebrafish K2P18.1 (TRESK) two-pore-domain K+ channels.
2014,
Pubmed
,
Xenbase
Rahm,
PKC-dependent activation of human K(2P) 18.1 K(+) channels.
2012,
Pubmed
,
Xenbase
Rajan,
TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor.
2000,
Pubmed
,
Xenbase
Rajan,
Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3.
2002,
Pubmed
,
Xenbase
Rajan,
THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels.
2001,
Pubmed
,
Xenbase
Riera,
Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels.
2009,
Pubmed
Sano,
A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord.
2003,
Pubmed
Silberstein,
Migraine genetics: Part II.
2013,
Pubmed
Sánchez-Miguel,
TRESK potassium channel in human T lymphoblasts.
2013,
Pubmed
Tsunozaki,
A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.
2013,
Pubmed
Tulleuda,
TRESK channel contribution to nociceptive sensory neurons excitability: modulation by nerve injury.
2011,
Pubmed
Valencia-Cruz,
K(bg) and Kv1.3 channels mediate potassium efflux in the early phase of apoptosis in Jurkat T lymphocytes.
2009,
Pubmed
Wright,
Cloxyquin (5-chloroquinolin-8-ol) is an activator of the two-pore domain potassium channel TRESK.
2013,
Pubmed
Yoo,
Regional expression of the anesthetic-activated potassium channel TRESK in the rat nervous system.
2009,
Pubmed
Yost,
Tandem pore domain K channels: an important site of volatile anesthetic action?
2000,
Pubmed
Zhou,
TRESK gene recombinant adenovirus vector inhibits capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons.
2012,
Pubmed
Zhou,
Intrathecal TRESK gene recombinant adenovirus attenuates spared nerve injury-induced neuropathic pain in rats.
2013,
Pubmed
Zhu,
Differential gene expression of neonatal and adult DRG neurons correlates with the differential sensitization of TRPV1 responses to nerve growth factor.
2011,
Pubmed
