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J Cell Biol September 29, 2014; 206 (7): 823-32.

Getting to know your neighbor: cell polarization in early embryos.

Nance J .

Polarization of early embryos along cell contact patterns--referred to in this paper as radial polarization--provides a foundation for the initial cell fate decisions and morphogenetic movements of embryogenesis. Although polarity can be established through distinct upstream mechanisms in Caenorhabditis elegans, Xenopus laevis, and mouse embryos, in each species, it results in the restriction of PAR polarity proteins to contact-free surfaces of blastomeres. In turn, PAR proteins influence cell fates by affecting signaling pathways, such as Hippo and Wnt, and regulate morphogenetic movements by directing cytoskeletal asymmetries.

PubMed ID: 25267293
PMC ID: PMC4178963
Article link: J Cell Biol
Grant support: [+]
Genes referenced: actl6a amot arhgap1 cdh1 cdx2 f2r llgl1 lrp6 mark2 mark3 nf2 notch1 pard3 pard6b prkci rho rho.2 tead4 yap1

Article Images: [+] show captions
References [+] :
Aceto, Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans. 2006, Pubmed

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