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Macrophages are integral to amphibian immunity against RVs, as well as to the infection strategies of these pathogens. Although CSF-1 was considered to be the principal mediator of macrophage development, the IL-34 cytokine, which shares no sequence identity with CSF-1, is now believed to contribute to vertebrate monopoiesis. However, the respective roles of CSF-1- and IL-34-derived macrophages are still poorly understood. To delineate the contribution of these macrophage populations to amphibian immunity against the RV FV3, we identified the Xenopus laevis IL-34 and transcriptionally and functionally compared this cytokine with the previously identified X. laevis CSF-1. The X. laevis CSF-1 and IL-34 displayed strikingly nonoverlapping developmental and tissue-specific gene-expression patterns. Furthermore, only CSF-1 but not IL-34 was up-regulated in the kidneys of FV3-challenged tadpoles. Intriguingly, recombinant forms of these cytokines (rXlCSF-1, rXlIL-34) elicited morphologically distinct tadpole macrophages, and whereas rXlCSF-1 pretreatment decreased the survival of FV3-infected tadpoles, rXlIL-34 administration significantly prolonged FV3-challenged animal survival. Compared with rXlIL-34-elicited macrophages, macrophages derived by rXlCSF-1 were more phagocytic but also significantly more susceptible to in vitro FV3 infections. By contrast, rXlIL-34-derived macrophages exhibited significantly greater in vitro antiranaviral activity and displayed substantially more robust gene expression of the NADPH oxidase components (p67(phox), gp91(phox)) and type I IFN. Moreover, FV3-challenged, rXlIL-34-derived macrophages exhibited several orders of magnitude greater up-regulation of the type I IFN gene expression. This marks the first report of the disparate roles of CSF-1 and IL-34 in vertebrate antiviral immunity.
Barreda,
Regulation of myeloid development and function by colony stimulating factors.
2004, Pubmed
Barreda,
Regulation of myeloid development and function by colony stimulating factors.
2004,
Pubmed
Baud'huin,
Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis.
2010,
Pubmed
Bayley,
Susceptibility of the European common frog Rana temporaria to a panel of ranavirus isolates from fish and amphibian hosts.
2013,
Pubmed
Beck,
The macrophage colony-stimulating factor 1 response signature in breast carcinoma.
2009,
Pubmed
Becker,
Experimental infection of Australian freshwater fish with epizootic haematopoietic necrosis virus (EHNV).
2013,
Pubmed
Belosevic,
Development of goldfish macrophages in vitro.
2006,
Pubmed
Chemel,
Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients.
2012,
Pubmed
Chen,
The critical role of IL-34 in osteoclastogenesis.
2011,
Pubmed
Chihara,
IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation.
2010,
Pubmed
Chinchar,
Ranaviruses (family Iridoviridae): emerging cold-blooded killers.
2002,
Pubmed
Chinchar,
Family Iridoviridae: poor viral relations no longer.
2009,
Pubmed
Coiras,
Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs.
2009,
Pubmed
Dai,
Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects.
2002,
Pubmed
De Jesús Andino,
Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogs.
2012,
Pubmed
,
Xenbase
Droin,
Editorial: CSF1R, CSF-1, and IL-34, a "menage a trois" conserved across vertebrates.
2010,
Pubmed
Eda,
Proinflammatory cytokines, IL-1β and TNF-α, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-κB pathway but not p38 pathway in osteoblasts.
2011,
Pubmed
Garceau,
Pivotal Advance: Avian colony-stimulating factor 1 (CSF-1), interleukin-34 (IL-34), and CSF-1 receptor genes and gene products.
2010,
Pubmed
Goodenow,
HIV-1 fitness and macrophages.
2003,
Pubmed
Gousset,
Real-time visualization of HIV-1 GAG trafficking in infected macrophages.
2008,
Pubmed
Gow,
Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34).
2013,
Pubmed
Gow,
Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34.
2012,
Pubmed
Grayfer,
The amphibian (Xenopus laevis) type I interferon response to frog virus 3: new insight into ranavirus pathogenicity.
2014,
Pubmed
,
Xenbase
Grayfer,
Macrophage colony-stimulating factor (CSF-1) induces pro-inflammatory gene expression and enhances antimicrobial responses of goldfish (Carassius auratus L.) macrophages.
2009,
Pubmed
Grayfer,
Colony-stimulating factor-1-responsive macrophage precursors reside in the amphibian (Xenopus laevis) bone marrow rather than the hematopoietic subcapsular liver.
2013,
Pubmed
,
Xenbase
Greter,
Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia.
2012,
Pubmed
Groot,
Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses.
2008,
Pubmed
Guilbert,
Specific interaction of murine colony-stimulating factor with mononuclear phagocytic cells.
1980,
Pubmed
Haislip,
Development and disease: how susceptibility to an emerging pathogen changes through anuran development.
2011,
Pubmed
Hanington,
Growth factors of lower vertebrates: characterization of goldfish (Carassius auratus L.) macrophage colony-stimulating factor-1.
2007,
Pubmed
Hoverman,
Anuran susceptibilities to ranaviruses: role of species identity, exposure route, and a novel virus isolate.
2010,
Pubmed
Hwang,
Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis.
2012,
Pubmed
Hyatt,
Comparative studies of piscine and amphibian iridoviruses.
2000,
Pubmed
Jancovich,
Transmission of the Ambystoma tigrinum virus to alternative hosts.
2001,
Pubmed
Jancovich,
Evidence for multiple recent host species shifts among the Ranaviruses (family Iridoviridae).
2010,
Pubmed
Landsberg,
Co-infection by alveolate parasites and frog virus 3-like ranavirus during an amphibian larval mortality event in Florida, USA.
2013,
Pubmed
Lichanska,
Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1.
1999,
Pubmed
Lin,
Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.
2008,
Pubmed
Liu,
The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
2012,
Pubmed
Ma,
Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.
2012,
Pubmed
Majji,
Transcriptome analysis of Frog virus 3, the type species of the genus Ranavirus, family Iridoviridae.
2009,
Pubmed
Morales,
Innate immune responses and permissiveness to ranavirus infection of peritoneal leukocytes in the frog Xenopus laevis.
2010,
Pubmed
,
Xenbase
Pixley,
CSF-1 regulation of the wandering macrophage: complexity in action.
2004,
Pubmed
Ramanayake,
In vivo study of T-cell responses to skin alloantigens in Xenopus using a novel whole-mount immunohistology method.
2007,
Pubmed
,
Xenbase
Reeve,
Natural stressors and ranavirus susceptibility in larval wood frogs (Rana sylvatica).
2013,
Pubmed
Robert,
Xenopus laevis: a possible vector of Ranavirus infection?
2007,
Pubmed
,
Xenbase
Thors,
On the development of the spinal cord of the clawed frog, Xenopus laevis. I. Morphogenesis and histogenesis.
1982,
Pubmed
,
Xenbase
Thors,
On the development of the spinal cord of the clawed frog, Xenopus laevis. II. Experimental analysis of differentiation and migration.
1982,
Pubmed
,
Xenbase
Venkatesh,
Elephant shark genome provides unique insights into gnathostome evolution.
2014,
Pubmed
Wang,
Interkeukin-34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and Langerhans cells.
2014,
Pubmed
Wang,
Two macrophage colony-stimulating factor genes exist in fish that differ in gene organization and are differentially expressed.
2008,
Pubmed
Wang,
Identification of IL-34 in teleost fish: differential expression of rainbow trout IL-34, MCSF1 and MCSF2, ligands of the MCSF receptor.
2013,
Pubmed
Wei,
Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells.
2010,
Pubmed
Williams,
A decade of advances in iridovirus research.
2005,
Pubmed
Yamane,
CSF-1 receptor-mediated differentiation of a new type of monocytic cell with B cell-stimulating activity: its selective dependence on IL-34.
2014,
Pubmed
