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Conditional deletion of α-CaMKII impairs integration of adult-generated granule cells into dentate gyrus circuits and hippocampus-dependent learning.
Arruda-Carvalho M
,
Restivo L
,
Guskjolen A
,
Epp JR
,
Elgersma Y
,
Josselyn SA
,
Frankland PW
.
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New granule cells are continuously integrated into hippocampal circuits throughout adulthood, and the fine-tuning of this process is likely important for efficient hippocampal function. During development, this integration process is critically regulated by the α-calcium/calmodulin-dependent protein kinase II (α-CaMKII), and here we ask whether this role is conserved in the adult brain. To do this, we developed a transgenic strategy to conditionally delete α-CaMKII from neural progenitor cells and their progeny in adult mice. First, we found that the selective deletion of α-CaMKII from newly generated dentate granule cells led to an increase in dendritic complexity. Second, α-CaMKII deletion led to a reduction in number of mature synapses and cell survival. Third, consistent with altered morphological and synaptic development, acquisition of one-trial contextual fear conditioning was impaired after deletion of α-CaMKII from newly generated dentate granule cells. Previous work in Xenopus identified α-CaMKII as playing a key role in the stabilization of dendritic and synaptic structure during development. The current study indicates that α-CaMKII plays a plays a similar, cell-autonomous role in the adult hippocampus and, in addition, reveals that the loss of α-CaMKII from adult-generated granule cells is associated with impaired hippocampus-dependent learning.
Achterberg,
Temporal and region-specific requirements of αCaMKII in spatial and contextual learning.
2014, Pubmed
Achterberg,
Temporal and region-specific requirements of αCaMKII in spatial and contextual learning.
2014,
Pubmed
Archer,
Tests for emotionality in rats and mice: a review.
1973,
Pubmed
Arruda-Carvalho,
Posttraining ablation of adult-generated neurons degrades previously acquired memories.
2011,
Pubmed
Barria,
NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII.
2005,
Pubmed
Bayer,
Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.
2006,
Pubmed
Buch,
A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.
2005,
Pubmed
Cancino,
p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior.
2013,
Pubmed
Chen,
Age- and sex-related disturbance in a battery of sensorimotor and cognitive tasks in Kunming mice.
2004,
Pubmed
Cline,
Dendritic arbor development and synaptogenesis.
2001,
Pubmed
Deng,
Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain.
2009,
Pubmed
Denny,
4- to 6-week-old adult-born hippocampal neurons influence novelty-evoked exploration and contextual fear conditioning.
2012,
Pubmed
Derkach,
Ca2+/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors.
1999,
Pubmed
Drew,
Arrest of adult hippocampal neurogenesis in mice impairs single- but not multiple-trial contextual fear conditioning.
2010,
Pubmed
Ge,
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain.
2007,
Pubmed
Goshima,
Overexpression of Ca2+/calmodulin-dependent protein kinase II in Neuro2a and NG108-15 neuroblastoma cell lines promotes neurite outgrowth and growth cone motility.
1993,
Pubmed
Gu,
Optical controlling reveals time-dependent roles for adult-born dentate granule cells.
2012,
Pubmed
Gundersen,
The efficiency of systematic sampling in stereology--reconsidered.
1999,
Pubmed
Guo,
Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning.
2011,
Pubmed
Hayashi,
Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction.
2000,
Pubmed
Hell,
CaMKII: claiming center stage in postsynaptic function and organization.
2014,
Pubmed
Hernández-Rabaza,
Inhibition of adult hippocampal neurogenesis disrupts contextual learning but spares spatial working memory, long-term conditional rule retention and spatial reversal.
2009,
Pubmed
Ihunwo,
Cell proliferation and total granule cell number in dentate gyrus of transgenic Tg2576 mouse.
2010,
Pubmed
Imayoshi,
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.
2008,
Pubmed
Katz,
Synaptic activity and the construction of cortical circuits.
1996,
Pubmed
Kempermann,
Milestones of neuronal development in the adult hippocampus.
2004,
Pubmed
Kheirbek,
NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination.
2012,
Pubmed
Kim,
Modality-specific retrograde amnesia of fear.
1992,
Pubmed
Ko,
Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory.
2009,
Pubmed
Lagace,
Dynamic contribution of nestin-expressing stem cells to adult neurogenesis.
2007,
Pubmed
Lisman,
Mechanisms of CaMKII action in long-term potentiation.
2012,
Pubmed
Lüthi,
Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity.
2004,
Pubmed
Massé,
Overexpression of Ca2+/calmodulin-dependent protein kinase II in PC12 cells alters cell growth, morphology, and nerve growth factor-induced differentiation.
1997,
Pubmed
Nakashiba,
Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion.
2012,
Pubmed
Pan,
Inhibition of adult neurogenesis by inducible and targeted deletion of ERK5 mitogen-activated protein kinase specifically in adult neurogenic regions impairs contextual fear extinction and remote fear memory.
2012,
Pubmed
Pattinson,
Aberrant dendritic branching and sensory inputs in the superficial dorsal horn of mice lacking CaMKIIalpha autophosphorylation.
2006,
Pubmed
Poncer,
Multiple mechanisms for the potentiation of AMPA receptor-mediated transmission by alpha-Ca2+/calmodulin-dependent protein kinase II.
2002,
Pubmed
Porsolt,
Animal model of depression.
1979,
Pubmed
Redmond,
Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription.
2002,
Pubmed
Rongo,
CaMKII regulates the density of central glutamatergic synapses in vivo.
1999,
Pubmed
Sahay,
Adult hippocampal neurogenesis in depression.
2007,
Pubmed
Scorcioni,
L-Measure: a web-accessible tool for the analysis, comparison and search of digital reconstructions of neuronal morphologies.
2008,
Pubmed
Shen,
Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation.
1999,
Pubmed
Shi,
Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation.
1999,
Pubmed
Stone,
Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory.
2011,
Pubmed
Sugiura,
Developmental changes in the levels of Ca2+/calmodulin-dependent protein kinase II alpha and beta proteins in soluble and particulate fractions of the rat brain.
1992,
Pubmed
Tang,
Alterations of CaMKII after hypoxia-ischemia during brain development.
2004,
Pubmed
Tashima,
Overexpression of Ca2+/calmodulin-dependent protein kinase II inhibits neurite outgrowth of PC12 cells.
1996,
Pubmed
Tashiro,
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus.
2006,
Pubmed
Tashiro,
Retrovirus-mediated single-cell gene knockout technique in adult newborn neurons in vivo.
2006,
Pubmed
Tronel,
Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons.
2010,
Pubmed
Wang,
Concomitant alterations of physiological and developmental plasticity in Drosophila CaM kinase II-inhibited synapses.
1994,
Pubmed
Warner-Schmidt,
Electroconvulsive seizure restores neurogenesis and hippocampus-dependent fear memory after disruption by irradiation.
2008,
Pubmed
Winocur,
Inhibition of neurogenesis interferes with hippocampus-dependent memory function.
2006,
Pubmed
Wu,
Dendritic dynamics in vivo change during neuronal maturation.
1999,
Pubmed
,
Xenbase
Wu,
Maturation of a central glutamatergic synapse.
1996,
Pubmed
,
Xenbase
Wu,
Stabilization of dendritic arbor structure in vivo by CaMKII.
1998,
Pubmed
,
Xenbase
Zambrowicz,
Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells.
1997,
Pubmed
Zhang,
A role for adult TLX-positive neural stem cells in learning and behaviour.
2008,
Pubmed
Zhao,
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus.
2006,
Pubmed
Zhou,
mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons.
2013,
Pubmed
Zou,
Postsynaptic calcium/calmodulin-dependent protein kinase II is required to limit elaboration of presynaptic and postsynaptic neuronal arbors.
1999,
Pubmed
,
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