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XB-ART-4976
Dev Biol July 15, 2003; 259 (2): 318-35.

Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation.

Tahinci E , Symes K .


Abstract
We have undertaken the first detailed analysis of Rho GTPase function during vertebrate development by analyzing how RhoA and Rac1 control convergent extension of axial mesoderm during Xenopus gastrulation. Monitoring of a number of parameters in time-lapse recordings of mesoderm explants revealed that Rac and Rho have both distinct and overlapping roles in regulating the motility of axial mesoderm cells. The cell behaviors revealed by activated or inhibitory versions of these GTPases in native tissue were clearly distinct from those previously documented in cultured fibroblasts. The dynamic properties and polarity of protrusive activity, along with lamellipodia formation, were controlled by the two GTPases operating in a partially redundant manner, while Rho and Rac contributed separately to cell shape and filopodia formation. We propose that Rho and Rac operate in distinct signaling pathways that are integrated to control cell motility during convergent extension.

PubMed ID: 12871704
Article link: Dev Biol
Grant support: [+]
Genes referenced: akt1 gsc mtor rac1 rho rho.2 rhoa tbxt
Antibodies: Notochord Ab1 Somite Ab1


Article Images: [+] show captions


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