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Haspin is an atypical mitotic kinase that phosphorylates histone H3 on threonine 3 (H3T3), which is required to target Aurora B to centromeres. However, how Haspin is activated upon mitotic entry remained unknown. Two independent studies, published in Molecular Cell and in this issue of EMBO reports by Ghenoiu et al and Zhou et al, respectively, now show that Plk1 is responsible for Haspin activation as a H3T3 kinase. These results shed light on the spatiotemporal regulation of Aurora B to ensure mitotic fidelity.
Campbell,
Tension sensing by Aurora B kinase is independent of survivin-based centromere localization.
2013, Pubmed
Campbell,
Tension sensing by Aurora B kinase is independent of survivin-based centromere localization.
2013,
Pubmed
Carmena,
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.
2012,
Pubmed
De Antoni,
A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B.
2012,
Pubmed
Eswaran,
Structure and functional characterization of the atypical human kinase haspin.
2009,
Pubmed
Ghenoiu,
Autoinhibition and Polo-dependent multisite phosphorylation restrict activity of the histone H3 kinase Haspin to mitosis.
2013,
Pubmed
,
Xenbase
Kelly,
Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B.
2010,
Pubmed
,
Xenbase
Wang,
Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation.
2012,
Pubmed
Wang,
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.
2010,
Pubmed
,
Xenbase
Wang,
A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis.
2011,
Pubmed
Zhou,
Polo-like kinase-1 triggers histone phosphorylation by Haspin in mitosis.
2014,
Pubmed
