Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-4995
FEBS Lett 2003 Jul 17;5471-3:37-42. doi: 10.1016/s0014-5793(03)00665-3.
Show Gene links Show Anatomy links

Modulation of Ca(v)3.2 T-type Ca2+ channels by protein kinase C.

Park JY , Jeong SW , Perez-Reyes E , Lee JH .


???displayArticle.abstract???
Although T-type Ca2+ channels have been implicated in numerous physiological functions, their regulations by protein kinases have been obscured by conflicting reports. We investigated the effects of protein kinase C (PKC) on Ca(v)3.2 T-type channels reconstituted in Xenopus oocytes. Phorbol-12-myristate-13-acetate (PMA) strongly enhanced the amplitude of Ca(v)3.2 channel currents (approximately 3-fold). The augmentation effects were not mimicked by 4alpha-PMA, an inactive stereoisomer of PMA, and abolished by preincubation with PKC inhibitors. Our findings suggest that PMA upregulates Ca(v)3.2 channel activity via activation of oocyte PKC.

???displayArticle.pubmedLink??? 12860383
???displayArticle.link??? FEBS Lett


Species referenced: Xenopus
Genes referenced: cacna1h