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XB-ART-49962
Dev Biol January 15, 2015; 397 (2): 237-47.

Sox21 regulates the progression of neuronal differentiation in a dose-dependent manner.

Whittington N , Cunningham D , Le TK , De Maria D , Silva EM .


Abstract
Members of the SoxB transcription factor family play critical roles in the regulation of neurogenesis. The SoxB1 proteins are required for the induction and maintenance of a proliferating neural progenitor population in numerous vertebrates, however the role of the SoxB2 protein, Sox21, is less clear due to conflicting results. To clarify the role of Sox21 in neurogenesis, we examined its function in the Xenopus neural plate. Here we report that misexpression of Sox21 expands the neural progenitor domain, and represses neuron formation by binding to Neurogenin (Ngn2) and blocking its function. Conversely, we found that Sox21 is also required for neuron formation, as cells lacking Sox21 undergo cell death and thus are unable to differentiate. Together our data indicate that Sox21 plays more than one role in neurogenesis, where a threshold level is required for cell viability and normal differentiation of neurons, but a higher concentration of Sox21 inhibits neuron formation and instead promotes progenitor maintenance.

PubMed ID: 25448693
PMC ID: PMC4325979
Article link: Dev Biol
Grant support: [+]
Genes referenced: eef1a2 krt12.4 myc myt1 neurod1 neurog1 neurog2 nog sox2 sox21 sox3 tubb2b
Morpholinos: sox21 MO1 sox21 MO2


Article Images: [+] show captions
References [+] :
Archer, Interaction of Sox1, Sox2, Sox3 and Oct4 during primary neurogenesis. 2011, Pubmed, Xenbase


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