Sato K .

Figure 1. Egg membrane microdomain-associated UPIII-Src system in Xenopus laevis. (A) Shown is a schematic diagram for the cell cycle conditions, and the activation/inactivation switching of the MPF (maturation-promoting factor), MAPK (mitogen-activated protein kinase), and UPIII (uroplakin III)-Src system, in the course of oogenesis, oocyte maturation, fertilization, and early embryogenesis in Xenopus laevis; (B) Illustrated are sperm-egg interaction at the level of each gamete’s plasma membrane and its associated signaling events that involve SGP (sperm surface glygoprotein) and MMP-2 (matrix metalloproteinase-2) in sperm and UPIII/UPIb (uroplakin Ib) complex, GM1, and Src in eggs. For details, see main text.

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