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XB-ART-50590
Cell Cycle January 1, 2015; 14 (12): 1799-808.

The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception.

Nagy V , Cole T , Van Campenhout C , Khoung TM , Leung C , Vermeiren S , Novatchkova M , Wenzel D , Cikes D , Polyansky AA , Kozieradzki I , Meixner A , Bellefroid EJ , Neely GG , Penninger JM .


Abstract
PR homology domain-containing member 12 (PRDM12) belongs to a family of conserved transcription factors implicated in cell fate decisions. Here we show that PRDM12 is a key regulator of sensory neuronal specification in Xenopus. Modeling of human PRDM12 mutations that cause hereditary sensory and autonomic neuropathy (HSAN) revealed remarkable conservation of the mutated residues in evolution. Expression of wild-type human PRDM12 in Xenopus induced the expression of sensory neuronal markers, which was reduced using various human PRDM12 mutants. In Drosophila, we identified Hamlet as the functional PRDM12 homolog that controls nociceptive behavior in sensory neurons. Furthermore, expression analysis of human patient fibroblasts with PRDM12 mutations uncovered possible downstream target genes. Knockdown of several of these target genes including thyrotropin-releasing hormone degrading enzyme (TRHDE) in Drosophila sensory neurons resulted in altered cellular morphology and impaired nociception. These data show that PRDM12 and its functional fly homolog Hamlet are evolutionary conserved master regulators of sensory neuronal specification and play a critical role in pain perception. Our data also uncover novel pathways in multiple species that regulate evolutionary conserved nociception.

PubMed ID: 25891934
PMC ID: PMC4613559
Article link: Cell Cycle

Genes referenced: isl1 nog prdm12 rara sncg tlx3 trhde
GO keywords: sensory perception of pain [+]
Morpholinos: prdm12 MO2 prdm12 MO3

Disease Ontology terms: hereditary sensory and autonomic neuropathy type 8
OMIMs: NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE VIII; HSAN8

Article Images: [+] show captions
References:
, 2015, Pubmed [+]


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