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XB-ART-50814
J Biochem 2014 Oct 01;1564:221-7. doi: 10.1093/jb/mvu034.
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Centromeric histone variant CENP-A represses acetylation-dependent chromatin transcription that is relieved by histone chaperone NPM1.

Shandilya J , Senapati P , Hans F , Menoni H , Bouvet P , Dimitrov S , Angelov D , Kundu TK .


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Mammalian centromeric histone H3 variant, CENP-A, is involved in maintaining the functional integrity and epigenetic inheritance of the centromere. CENP-A causes transcriptional repression of centromeric chromatin through an unknown mechanism. Here, we report that reconstituted CENP-A nucleosomes are amenable to ATP-dependent SWI/SNF-mediated remodelling but are less permissive to acetylation and acetylation-dependent in vitro chromatin transcription. Remarkably, the transcriptional repression of the CENP-A chromatinized template could be relieved by the ectopic addition of histone chaperone, nucleophosmin.

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Species referenced: Xenopus laevis
Genes referenced: cenpa npm1