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Sci Rep September 21, 2015; 5 11157.

Intracellular microRNA profiles form in the Xenopus laevis oocyte that may contribute to asymmetric cell division.

Sidova M , Sindelka R , Castoldi M , Benes V , Kubista M .

Asymmetric distribution of fate determinants within cells is an essential biological strategy to prepare them for asymmetric division. In this work we measure the intracellular distribution of 12 maternal microRNAs (miRNA) along the animal-vegetal axis of the Xenopus laevis oocyte using qPCR tomography. We find the miRNAs have distinct intracellular profiles that resemble two out of the three profiles we previously observed for mRNAs. Our results suggest that miRNAs in addition to proteins and mRNAs may have asymmetric distribution within the oocyte and may contribute to asymmetric cell division as cell fate determinants.

PubMed ID: 26059897
PMC ID: PMC4461913
Article link: Sci Rep

Species referenced: Xenopus laevis
Genes referenced: cdx1 gdf1 maml1 sst.1 tbl1x

Article Images: [+] show captions
References [+] :
Ambady, Identification of novel microRNAs in Xenopus laevis metaphase II arrested eggs. 2012, Pubmed, Xenbase