Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-50852
Development July 1, 2015; 142 (13): 2352-63.

BMP signalling controls the construction of vertebrate mucociliary epithelia.

Cibois M , Luxardi G , Chevalier B , Thomé V , Mercey O , Zaragosi LE , Barbry P , Pasini A , Marcet B , Kodjabachian L .


Abstract
Despite the importance of mucociliary epithelia in animal physiology, the mechanisms controlling their establishment are poorly understood. Using the developing Xenopus epidermis and regenerating human upper airways, we reveal the importance of BMP signalling for the construction of vertebrate mucociliary epithelia. In Xenopus, attenuation of BMP activity is necessary for the specification of multiciliated cells (MCCs), ionocytes and small secretory cells (SSCs). Conversely, BMP activity is required for the proper differentiation of goblet cells. Our data suggest that the BMP and Notch pathways interact to control fate choices in the developing epidermis. Unexpectedly, BMP activity is also necessary for the insertion of MCCs, ionocytes and SSCs into the surface epithelium. In human, BMP inhibition also strongly stimulates the formation of MCCs in normal and pathological (cystic fibrosis) airway samples, whereas BMP overactivation has the opposite effect. This work identifies the BMP pathway as a key regulator of vertebrate mucociliary epithelium differentiation and morphogenesis.

PubMed ID: 26092849
Article link: Development

Genes referenced: ank1 atp6v1a bmp2 bmp4 bmp7.1 bmp7.2 bmpr1a dag1 dll1 foxa1 foxi1 foxj1 foxj1.2 h3-3a itln1 mcc mcidas nog notch1 otogl2 smad1 smad9 tgm1 tp63 tph1 trim29 tuba4b
GO keywords: Notch signaling pathway [+]
Antibodies: H3f3a Ab9 Smad1 Ab7 Tp63 Ab3 Tuba4b Ab4
Morpholinos: bmp2 MO1 bmp4 MO1 bmp7.2 MO1

Disease Ontology terms: cystic fibrosis
OMIMs: CYSTIC FIBROSIS; CF

Article Images: [+] show captions


Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.12.0


Major funding for Xenbase is provided by grant P41 HD064556