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XB-ART-50854
Dev Biol May 1, 2014; 389 (1): 2-12.

Setting appropriate boundaries: fate, patterning and competence at the neural plate border.

Groves AK , LaBonne C .


Abstract
The neural crest and craniofacial placodes are two distinct progenitor populations that arise at the border of the vertebrate neural plate. This border region develops through a series of inductive interactions that begins before gastrulation and progressively divide embryonic ectoderm into neural and non-neural regions, followed by the emergence of neural crest and placodal progenitors. In this review, we describe how a limited repertoire of inductive signals-principally FGFs, Wnts and BMPs-set up domains of transcription factors in the border region which establish these progenitor territories by both cross-inhibitory and cross-autoregulatory interactions. The gradual assembly of different cohorts of transcription factors that results from these interactions is one mechanism to provide the competence to respond to inductive signals in different ways, ultimately generating the neural crest and cranial placodes.

PubMed ID: 24321819
PMC ID: PMC3972267
Article link: Dev Biol

Genes referenced: bmp4 bmp7.1 bmp7.2 dlx5 dlx6 ern1 eya1 eya2 fgf4 fgf8 foxd3 foxi1 gata2 gata3 gmnn irx1 msx1 myc otx2 pax3 pax7 six1 six2 six3 six4 six6 sox2 sox3


Article Images: [+] show captions
References:
Abdelhak, 1997, Pubmed [+]


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