XB-ART-50859Science May 15, 2009; 324 (5929): 941-4.
In vertebrates, the readily apparent left/right (L/R) anatomical asymmetries of the internal organs can be traced to molecular events initiated at or near the time of gastrulation. However, the earliest steps of this process do not seem to be universally conserved. In particular, how this axis is first defined in chicks has remained problematic. Here we show that asymmetric cell rearrangements take place within chick embryos, creating a leftward movement of cells around the node. It is the relative displacement of cells expressing sonic hedgehog (Shh) and fibroblast growth factor 8 (Fgf8) that is responsible for establishing their asymmetric expression patterns. The creation of asymmetric expression domains as a passive effect of cell movements represents an alternative strategy for breaking L/R symmetry in gene activity.
PubMed ID: 19359542
PMC ID: PMC2993078
Article link: Science
Genes referenced: fgf8 shh
References [+] :
Cui, Rotation of organizer tissue contributes to left-right asymmetry. 2009, Pubmed