XB-ART-50947
Nat Rev Mol Cell Biol
2015 Aug 01;168:455-60. doi: 10.1038/nrm4015.
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DNA-protein crosslink repair.
Stingele J
,
Jentsch S
.
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DNA-protein crosslinks (DPCs) are highly toxic DNA adducts, but whether dedicated DPC-repair mechanisms exist was until recently unknown. This has changed with discoveries made in yeast and Xenopus laevis that revealed a protease-based DNA-repair pathway specific for DPCs. Importantly, mutations in the gene encoding the putative human homologue of a yeast DPC protease cause a human premature ageing and cancer predisposition syndrome. Thus, DPC repair is a previously overlooked genome-maintenance mechanism that may be essential for tumour suppression.
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