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XB-ART-50973
Dev Comp Immunol November 1, 2015; 53 (1): 158-68.

Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis.

Guselnikov SV , Grayfer L , De Jesús Andino F , Rogozin IB , Robert J , Taranin AV .


Abstract
The ITAM-bearing transmembrane signaling subunits (TSS) are indispensable components of activating leukocyte receptor complexes. The TSS-encoding genes map to paralogous chromosomal regions, which are thought to arise from ancient genome tetraploidization(s). To assess a possible role of tetraploidization in the TSS evolution, we studied TSS and other functionally linked genes in the amphibian species Xenopus laevis whose genome was duplicated about 40 MYR ago. We found that X. laevis has retained a duplicated set of sixteen TSS genes, all except one being transcribed. Furthermore, duplicated TCRα loci and genes encoding TSS-coupling protein kinases have also been retained. No clear evidence for functional divergence of the TSS paralogs was obtained from gene expression and sequence analyses. We suggest that the main factor of maintenance of duplicated TSS genes in X. laevis was a protein dosage effect and that this effect might have facilitated the TSS set expansion in early vertebrates.

PubMed ID: 26170006
PMC ID: PMC4536121
Article link: Dev Comp Immunol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: abhd4 aplp1 arf1 arhgef1 cct3 cd247 cd3e cd3g cd79a cd79b chd8 creg1 dad1 dedd fcrg gapdh gh1 glmp hcst mettl3 mpzl2 mpzl3 myc ndufs2 nfkbid nphs1 pou2f1 pou2f2 psmc5 rab2b rabac1 sall2 scn4a tox4 tyrobp ube4a zmym1l


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References [+] :
Alabyev, CD3epsilon homologues in the chondrostean fish Acipenser ruthenus. 2000, Pubmed, Xenbase