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Ca2+-calmodulin-dependent protein kinase II potentiates store-operated Ca2+ current.
Machaca K
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A rise in intracellular Ca2+ (Ca2+i) mediates various cellular functions ranging from fertilization to gene expression. A ubiquitous Ca2+ influx pathway that contributes significantly to the generation of Ca2+i signals, especially in non-excitable cells, is store-operated Ca2+ entry (SOCE). Consequently, the modulation of SOCE current affects Ca2+i dynamics and thus the ensuing cellular response. Therefore, it is important to define the mechanisms that regulate SOCE. Here we show that a rise in Ca2+i potentiates SOCE. This potentiation is mediated by Ca2+-calmodulin-dependent protein kinase II (CaMKII), because inhibition of endogenous CaMKII activity abrogates Ca2+i-mediated SOCE potentiation and expression of constitutively active CaMKII potentiates SOCE current independently of Ca2+i. Moreover, we present evidence that CaMKII potentiates SOCE by altering SOCE channel gating. The regulation of SOCE by CaMKII defines a novel modulatory mechanism of SOCE with important physiological consequences.
Barrett,
Stimulation of unitary T-type Ca(2+) channel currents by calmodulin-dependent protein kinase II.
2000, Pubmed
Barrett,
Stimulation of unitary T-type Ca(2+) channel currents by calmodulin-dependent protein kinase II.
2000,
Pubmed
Christian,
Calcium-dependent enhancement of depletion-activated calcium current in Jurkat T lymphocytes.
1996,
Pubmed
De Koninck,
Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations.
1998,
Pubmed
Dzhura,
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels.
2000,
Pubmed
Fanger,
Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.
1995,
Pubmed
Fomina,
A current activated on depletion of intracellular Ca2+ stores can regulate exocytosis in adrenal chromaffin cells.
1999,
Pubmed
Gailly,
Role of [Ca2+]i in "Ca2+ stores depletion-Ca2+ entry coupling' in fibroblasts expressing the rat neurotensin receptor.
1996,
Pubmed
Hanson,
Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals.
1994,
Pubmed
Hartzell,
Activation of different Cl currents in Xenopus oocytes by Ca liberated from stores and by capacitative Ca influx.
1996,
Pubmed
,
Xenbase
Hook,
Ca(2+)/CaM-dependent kinases: from activation to function.
2001,
Pubmed
Hoth,
Calcium release-activated calcium current in rat mast cells.
1993,
Pubmed
Hoth,
Depletion of intracellular calcium stores activates a calcium current in mast cells.
1992,
Pubmed
Hudmon,
Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function.
2002,
Pubmed
Ishida,
A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II.
1995,
Pubmed
Kuruma,
Bimodal control of a Ca(2+)-activated Cl(-) channel by different Ca(2+) signals.
2000,
Pubmed
,
Xenbase
Lewis,
Store-operated calcium channels.
1999,
Pubmed
Machaca,
Reversible Ca gradients between the subplasmalemma and cytosol differentially activate Ca-dependent Cl currents.
1999,
Pubmed
,
Xenbase
Machaca,
Store-operated calcium entry inactivates at the germinal vesicle breakdown stage of Xenopus meiosis.
2000,
Pubmed
,
Xenbase
Machaca,
Induction of maturation-promoting factor during Xenopus oocyte maturation uncouples Ca(2+) store depletion from store-operated Ca(2+) entry.
2002,
Pubmed
,
Xenbase
Matifat,
Involvement of the Ca2+/calmodulin-dependent protein kinase II pathway in the Ca2+-mediated regulation of the capacitative Ca2+ entry in Xenopus oocytes.
1997,
Pubmed
,
Xenbase
McCarron,
Calcium-dependent enhancement of calcium current in smooth muscle by calmodulin-dependent protein kinase II.
1992,
Pubmed
Norwood,
Store-operated calcium entry and increased endothelial cell permeability.
2000,
Pubmed
O'Toole,
Ca(2+) entry through store-operated channels in mouse sperm is initiated by egg ZP3 and drives the acrosome reaction.
2000,
Pubmed
Parekh,
The store-operated calcium current I(CRAC): nonlinear activation by InsP3 and dissociation from calcium release.
1997,
Pubmed
Parekh,
Store depletion and calcium influx.
1997,
Pubmed
Parekh,
Ca2+ oscillations and Ca2+ influx in Xenopus oocytes expressing a novel 5-hydroxytryptamine receptor.
1993,
Pubmed
,
Xenbase
Parekh,
Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells.
1995,
Pubmed
Petersen,
The regulation of capacitative calcium entry by calcium and protein kinase C in Xenopus oocytes.
1994,
Pubmed
,
Xenbase
Quick,
Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes.
1994,
Pubmed
,
Xenbase
Serafini,
Isolation of mutant T lymphocytes with defects in capacitative calcium entry.
1995,
Pubmed
Shen,
Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation.
1999,
Pubmed
Srinivasan,
Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus.
1994,
Pubmed
Stevens,
Cloning and differential expression of new calcium, calmodulin-dependent protein kinase II isoforms in Xenopus laevis oocytes and several adult tissues.
2001,
Pubmed
,
Xenbase
Vazquez,
Involvement of calmodulin in 1alpha,25-dihydroxyvitamin D3 stimulation of store-operated Ca2+ influx in skeletal muscle cells.
2000,
Pubmed
Waldmann,
Multifunctional Ca2+/calmodulin-dependent protein kinase made Ca2+ independent for functional studies.
1990,
Pubmed
,
Xenbase
Yao,
Calcium current activated by depletion of calcium stores in Xenopus oocytes.
1997,
Pubmed
,
Xenbase
Zweifach,
Calcium-dependent potentiation of store-operated calcium channels in T lymphocytes.
1996,
Pubmed
Zweifach,
Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback.
1995,
Pubmed
Zweifach,
Slow calcium-dependent inactivation of depletion-activated calcium current. Store-dependent and -independent mechanisms.
1995,
Pubmed
