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XB-ART-51051
Int J Dev Biol January 1, 2014; 58 (10-12): 841-9.

Comparative expression analysis of cysteine-rich intestinal protein family members crip1, 2 and 3 during Xenopus laevis embryogenesis.

Hempel A , Kühl SJ .


Abstract
Members of the cysteine-rich intestinal protein (Crip) family belong to the group 2 LIM proteins. Crip proteins are widely expressed in adult mammals but their expression profile and function during embryonic development are still mostly unknown. In this study, we have described for the first time the spatio-temporal expression pattern of the three family members crip1, crip2 and crip3 during Xenopus laevis embryogenesis by RT-PCR and whole mount in situ hybridization approaches. We observed that all three genes are expressed in the pronephros, branchial arches and the eye. Furthermore, crip1 transcripts could be visualized in the developing cranial ganglia and neural tube. In contrast, crip2 could be detected in the cardiovascular system, the brain and the neural tube while crip3 was expressed in the cranial ganglions and the heart. Based on these findings, we suggest that each crip family member may play an important role during embryonic development.

PubMed ID: 26154325
Article link: Int J Dev Biol

Genes referenced: abcc1 abcc10 asxl2 brf1 cftr crip1 crip2 crip3 cul9 dlk2 dnph1 igh lhx1 mapt mta1 pacs2 pex2 plin1 ptgr2 rnf8 rpe rtf1 slc22a7 slc25a21 tmem121 tmem229b tmem62 ttbk1 zfp36l1 znf318


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