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Cell Adh Migr January 1, 2014; 8 (4): 308-26.

Ephrin-Eph signaling in embryonic tissue separation.

The physical separation of the embryonic regions that give rise to the tissues and organs of multicellular organisms is a fundamental aspect of morphogenesis. Pioneer experiments by Holtfreter had shown that embryonic cells can sort based on "tissue affinities," which have long been considered to rely on differences in cell-cell adhesion. However, vertebrate embryonic tissues also express a variety of cell surface cues, in particular ephrins and Eph receptors, and there is now firm evidence that these molecules are systematically used to induce local repulsion at contacts between different cell types, efficiently preventing mixing of adjacent cell populations.

PubMed ID: 25482630
PMC ID: PMC4594459
Article link: Cell Adh Migr

Genes referenced: efna1 efna3 efna4 efna5 efnb2 efnb3 epha10 epha2 epha3 epha4 epha5 epha7 epha8 ephb1 ephb2 ephb3 ephb4

Article Images: [+] show captions
References [+] :
Aliee, Physical mechanisms shaping the Drosophila dorsoventral compartment boundary. 2012, Pubmed

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