Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-51135
Cell 1993 Mar 12;725:681-93.
Show Gene links Show Anatomy links

kelch encodes a component of intercellular bridges in Drosophila egg chambers.

Xue F , Cooley L .


???displayArticle.abstract???
Oocyte maturation in Drosophila is supported by a cluster of 15 germline-derived nurse cells whose cytoplasm is transported into the oocyte through intercellular bridges called ring canals. kelch was isolated as a female sterile mutation affecting cytoplasm transport. We have cloned the kelch gene and found that it encodes an unusual transcript containing two open reading frames (ORF1 and ORF2) separated by a single UGA stop codon. At least two protein products are made from the kelch mRNA: a short protein from ORF1 and a longer protein from both ORF1 and ORF2 as a result of partial suppression of the UGA codon. The kelch ORF1 product is conserved, and antibodies directed against it are localized specifically to ring canals. Our results suggest that kelch produces a component of ring canals that regulates the flow of cytoplasm between cells.

???displayArticle.pubmedLink??? 8453663
???displayArticle.link??? Cell


Species referenced: Xenopus
Genes referenced: klhl2
???displayArticle.antibodies??? klhl2 Ab1