Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-51224
Mol Biol Cell. September 6, 2017;

Global analysis of asymmetric RNA enrichment in oocytes reveals low conservation between closely related Xenopus species.

Claußen M , Lingner T , Pommerenke C , Opitz L , Salinas G , Pieler T .


Abstract
RNAs that localize to the vegetal cortex during Xenopus laevis oogenesis have been reported to function in germ layer patterning, axis determination and development of the primordial germ cells. Here we report on the genome-wide, comparative analysis of differentially localizing RNAs in Xenopus laevis and Xenopus tropicalis oocytes, revealing a surprisingly weak degree of conservation in respect to the identity of animally as well as vegetally enriched transcripts in these closely related species. Heterologous RNA injections and protein binding studies indicate that the different RNA localization patterns in these two species are due to gain/loss of cis-acting localization signals rather than to differences in the RNA localizing machinery.

PubMed ID: 26337391
PMC ID: PMC4626063
Article link: Mol Biol Cell.

Genes referenced: acp6 aen armc5 atrx cnksr2 fndc3a frmd8 gdf1 grip2 krt8 lima1 magi1 mogat1 pgam1 pld2 ppp1r2 slc12a9 slc18a1 sox7 tob2 tuft1


References:
Allison, 2004, Pubmed, Xenbase[+]


Article Images: [+] show captions

My Xenbase: [ Log-in / Register ]
version: [4.6.0]

Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556