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XB-ART-51230
PLoS One January 1, 2015; 10 (9): e0136929.
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Genome-Wide Identification and Expression of Xenopus F-Box Family of Proteins.

Saritas-Yildirim B , Pliner HA , Ochoa A , Silva EM .


Abstract
Protein degradation via the multistep ubiquitin/26S proteasome pathway is a rapid way to alter the protein profile and drive cell processes and developmental changes. Many key regulators of embryonic development are targeted for degradation by E3 ubiquitin ligases. The most studied family of E3 ubiquitin ligases is the SCF ubiquitin ligases, which use F-box adaptor proteins to recognize and recruit target proteins. Here, we used a bioinformatics screen and phylogenetic analysis to identify and annotate the family of F-box proteins in the Xenopus tropicalis genome. To shed light on the function of the F-box proteins, we analyzed expression of F-box genes during early stages of Xenopus development. Many F-box genes are broadly expressed with expression domains localized to diverse tissues including brain, spinal cord, eye, neural crest derivatives, somites, kidneys, and heart. All together, our genome-wide identification and expression profiling of the Xenopus F-box family of proteins provide a foundation for future research aimed to identify the precise role of F-box dependent E3 ubiquitin ligases and their targets in the regulatory circuits of development.

PubMed ID: 26327321
PMC ID: PMC4556705
Article link: PLoS One
Grant support: [+]

Species referenced: Xenopus tropicalis
Genes referenced: btrc ccnf eloa fbxl14 fbxl15 fbxl19 fbxl22 fbxl3 fbxo11 fbxo28 fbxo3 fbxo33 fbxo43 fbxo46 fbxo7 fbxo8 fbxo9 fbxw2 fbxw7 fbxw9 gnat1 kdm2b odc1 tnf XB5721468 [provisional] XB5727064 [provisional] XB5799768 [provisional] XB5964270 [provisional:fbxw7]


Article Images: [+] show captions
References [+] :
Altschul, Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. 1997, Pubmed