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Cells September 11, 2015; 4 (3): 483-99.

Nephron Patterning: Lessons from Xenopus, Zebrafish, and Mouse Studies.

Desgrange A , Cereghini S .

The nephron is the basic structural and functional unit of the vertebrate kidney. To ensure kidney functions, the nephrons possess a highly segmental organization where each segment is specialized for the secretion and reabsorption of particular solutes. During embryogenesis, nephron progenitors undergo a mesenchymal-to-epithelial transition (MET) and acquire different segment-specific cell fates along the proximo-distal axis of the nephron. Even if the morphological changes occurring during nephrogenesis are characterized, the regulatory networks driving nephron segmentation are still poorly understood. Interestingly, several studies have shown that the pronephric nephrons in Xenopus and zebrafish are segmented in a similar fashion as the mouse metanephric nephrons. Here we review functional and molecular aspects of nephron segmentation with a particular interest on the signaling molecules and transcription factors recently implicated in kidney development in these three different vertebrate model organisms. A complete understanding of the mechanisms underlying nephrogenesis in different model organisms will provide novel insights on the etiology of several human renal diseases.

PubMed ID: 26378582
PMC ID: PMC4588047
Article link: Cells

Genes referenced: dct ercc6 slc7a5 ssb sult1a1 tff3.1 tnfsf13b

Article Images: [+] show captions
References [+] :
Alarcón, A dual requirement for Iroquois genes during Xenopus kidney development. 2008, Pubmed, Xenbase

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