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Development October 1, 2014; 141 (20): 3834-41.

New insights into the maternal to zygotic transition.

Langley AR , Smith JC , Stemple DL , Harvey SA .

The initial phases of embryonic development occur in the absence of de novo transcription and are instead controlled by maternally inherited mRNAs and proteins. During this initial period, cell cycles are synchronous and lack gap phases. Following this period of transcriptional silence, zygotic transcription begins, the maternal influence on development starts to decrease, and dramatic changes to the cell cycle take place. Here, we discuss recent work that is shedding light on the maternal to zygotic transition and the interrelated but distinct mechanisms regulating the onset of zygotic transcription and changes to the cell cycle during early embryonic development.

PubMed ID: 25294937
Article link: Development
Grant support: A252-5RG50 Medical Research Council , MC_U117597140 Medical Research CouncilWellcome Trust , MRC_MC_U117597140 Medical Research Council

Genes referenced: ccna1 ccnb1 cdc6 cdk1 dnmt1 sox2 sox3

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