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XB-ART-51615
Gene Expr Patterns January 1, 2016; 20 (1): 55-62.

Expression pattern of bcar3, a downstream target of Gata2, and its binding partner, bcar1, during Xenopus development.

Green YS , Kwon S , Christian JL .


Abstract
Primitive hematopoiesis generates red blood cells that deliver oxygen to the developing embryo. Mesodermal cells commit to a primitive blood cell fate during gastrulation and, in order to do so the mesoderm must receive non-cell autonomous signals transmitted from other germ layers. In Xenopus, the transcription factor Gata2 functions in ectodermal cells to generate or transmit the non-cell autonomous signals. Here we have identified Breast Cancer Antiestrogen Resistance 3 (bcar3) as a gene that is induced in ectodermal cells downstream of Gata2. Bcar3 and its binding partner Bcar1 function to transduce integrin signaling, leading to changes in cellular morphology, motility and adhesion. We show that gata2, bcar3 and bcar1 are co-expressed in ventral ectoderm from early gastrula to early tailbud stages. At later stages of development, bcar3 and bcar1 are co-expressed in the spinal cord, notochord, fin mesenchyme and pronephros but each shows additional unique sites of expression. These co-expression and unique expression patterns suggest that Bcar3 and Bcar1 may function together but also independently during Xenopus development.

PubMed ID: 26631802
PMC ID: PMC4733426
Article link: Gene Expr Patterns
Grant support: [+]
Genes referenced: bcar1 bcar3 foxi1 gata2 sox17a tbxt zfpm1
GO keywords: cell fate commitment [+]

OMIMs: BREAST CANCER

Article Images: [+] show captions
References:
Baron, 2003, Pubmed [+]


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