Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Fish Physiol Biochem
2016 Jun 01;423:1053-61. doi: 10.1007/s10695-016-0196-4.
Show Gene links
Show Anatomy links
Expression of mep50 in adult and embryos of medaka fish (Oryzias latipes).
Cheng N
,
Guo M
,
Chang P
,
Zhang X
,
Zhang R
,
Qi C
,
Zhong X
,
Zhou Q
,
Zhao H
.
???displayArticle.abstract???
Protein arginine methylation is important for gene regulation and biological processes. Methylosome protein 50 (Mep50) is identified as a partner of protein arginine methyltransferase 5 (Prmt5), a major enzyme capable of symmetric dimethylation, in mammals and Xenopus. The isolation and characterization of medaka mep50 were reported in this paper. Medaka Mep50 is a homolog of human MEP50 with six WD40 domains. Medaka mep50 was ubiquitously expressed in the adult tissues and had maternal origin with continuous and dynamical expression during embryonic development detected by RT-PCR and in situ hybridization. A strong interaction of medaka Mep50 and Prmt5 was shown by yeast two hybridization. The expression pattern of mep50 is similar to that of prmt5 in medaka. The results suggested that medaka Mep50 could be a partner of Prmt5 and might play major roles in a variety of tissues in medaka.
Aggarwal,
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.
2010, Pubmed
Aggarwal,
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.
2010,
Pubmed
Amente,
Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation.
2005,
Pubmed
Ancelin,
Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells.
2006,
Pubmed
Anne,
Valois, a component of the nuage and pole plasm, is involved in assembly of these structures, and binds to Tudor and the methyltransferase Capsuléen.
2005,
Pubmed
Anne,
Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila.
2007,
Pubmed
Antonysamy,
Crystal structure of the human PRMT5:MEP50 complex.
2012,
Pubmed
Bedford,
Protein arginine methylation in mammals: who, what, and why.
2009,
Pubmed
Boisvert,
Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing.
2002,
Pubmed
Cavey,
Drosophila valois encodes a divergent WD protein that is required for Vasa localization and Oskar protein accumulation.
2005,
Pubmed
Chen,
Expression pattern of prmt5 in adult fish and embryos of medaka, Oryzias latipes.
2009,
Pubmed
Chung,
Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing.
2013,
Pubmed
Dacwag,
The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling.
2007,
Pubmed
Friesen,
A novel WD repeat protein component of the methylosome binds Sm proteins.
2002,
Pubmed
Furuno,
Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro.
2006,
Pubmed
Gonsalvez,
The Sm-protein methyltransferase, dart5, is essential for germ-cell specification and maintenance.
2006,
Pubmed
Guderian,
RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.
2011,
Pubmed
Ho,
Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity.
2013,
Pubmed
,
Xenbase
Hosohata,
Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription.
2003,
Pubmed
Jansson,
Arginine methylation regulates the p53 response.
2008,
Pubmed
Kirino,
Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability.
2009,
Pubmed
,
Xenbase
Licciardo,
The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP.
2003,
Pubmed
Ligr,
Expression and function of androgen receptor coactivator p44/Mep50/WDR77 in ovarian cancer.
2011,
Pubmed
Mallappa,
The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4.
2011,
Pubmed
Meister,
Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.
2001,
Pubmed
,
Xenbase
Nagamatsu,
A germ cell-specific gene, Prmt5, works in somatic cell reprogramming.
2011,
Pubmed
Neuenkirchen,
Deciphering the assembly pathway of Sm-class U snRNPs.
2008,
Pubmed
Nicholas,
PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.).
2013,
Pubmed
Page,
TreeView: an application to display phylogenetic trees on personal computers.
1996,
Pubmed
Pal,
mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.
2003,
Pubmed
Peng,
Androgen receptor coactivator p44/Mep50 in breast cancer growth and invasion.
2010,
Pubmed
Richard,
Arginine methylation regulates IL-2 gene expression: a role for protein arginine methyltransferase 5 (PRMT5).
2005,
Pubmed
Scoumanne,
PRMT5 is required for cell-cycle progression and p53 tumor suppressor function.
2009,
Pubmed
Smith,
The WD repeat: a common architecture for diverse functions.
1999,
Pubmed
Tee,
Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency.
2010,
Pubmed
Yang,
Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis.
2009,
Pubmed
Zhao,
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.
2009,
Pubmed
Zhao,
Ol4E-T, a eukaryotic translation initiation factor 4E-binding protein of medaka fish (Oryzias latipes), can interact with nanos3 and vasa in vitro.
2013,
Pubmed
